A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity
A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity
复制标题
Scalloped 的新伙伴通过拮抗 Scalloped-Yorkie 活性来调节 Hippo 信号传导
DOI：
10.1038/cr.2013.120
复制
发表时间：
2013-10-01
期刊：
影响因子：
44.1
通讯作者：
Zhang, Lei
中科院分区：
文献类型：
--
作者：
Guo, Tong;Lu, Yi;Zhang, Lei
Hippo（Hpo）途径通过调节转录共激活因子Yorkie（Yki）的活性来控制组织生长和器官大小，所述转录共激活因子Yorkie（Yki）与细胞核中的转录因子Scalloped（Sd）相关联以促进下游靶基因表达。在这里，我们确定了一种新的蛋白质Sd结合蛋白（SdBP）/Tgi，它直接竞争与Yki的结合，Sd通过其TDU结构域和抑制Sd-Yki的转录活性。我们还发现，SdBP保留Yki在核中通过协会与Yki WW域通过其PPXY基序。总的来说，我们确定SdBP作为Hpo途径的一个新的组成部分，负调节Sd-Yki的转录活性，以限制组织生长。
The Hippo (Hpo) pathway controls tissue growth and organ size by regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth.