Regional biomechanical and failure properties of healthy human ascending aorta and root.
Regional biomechanical and failure properties of healthy human ascending aorta and root.
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DOI：
10.1016/j.jmbbm.2021.104705
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发表时间：
2021-11
影响因子：
3.9
通讯作者：
Ge L
中科院分区：
文献类型：
--
作者：
Xuan Y;Wisneski AD;Wang Z;Lum M;Kumar S;Pallone J;Flores N;Inman J;Lai L;Lin J;Guccione JM;Tseng EE;Ge L
主动脉夹层（AD）是一种危及生命的事件，发生在内膜入口撕裂扩展并将主动脉内层与外层分离时。动脉瘤修复的当前标准直径远不理想，优化临床决策的额外证据将非常有益。主动脉组织局部失效特性的生物力学研究对于了解和主动预防AD至关重要。我们以前研究了健康人主动脉的双轴力学性能。在这项研究中，我们调查了健康人升主动脉（AscAo）的区域故障的属性，包括窦的Valsalva（SOV），窦管连接（STJ）。共430个完整的组织样本，从19个健康供体的心脏被排除在心脏移植。供体的平均年龄为51 ± 11.7岁，性别分布几乎相等。在规定位置从主动脉区域和亚区域切除样本。对组织条进行双轴或单轴失效测试。壁厚区域性变化，AscAo最厚（2.08 ± 0.66 mm），SOV最薄（1.46 ± 0.31 mm）。双轴试验证实了主动脉组织的增生行为。在圆周和纵向上，后部和外侧STJ子区域比前部和内侧子区域更硬。在AscAo、STJ和SOV的每个子区域中，周向的失效应力显著高于纵向。AscAo的纵向破坏应力显著大于STJ或SOV。AscAo的纵向失效应力前部远小于后部，内侧远小于外侧。窦管连接处沿着纵向最弱区域的发现证实了该区域通常作为主动脉夹层内膜撕裂初始部位的临床观察结果。断裂拉伸比与每个区域的弹性模量相关。此外，在生理压力下，沿周向和纵向，STJ失效应力和弹性模量之间存在很强的相关性。将基于体内成像的体内主动脉弹性模量与生理压力和失效应力下实验确定的弹性模量相关联，可能会提供有关主动脉壁强度的有价值信息。更好地了解正常生理和动脉瘤病理状态下的主动脉生物力学有助于确定预测患者特定方式夹层的风险因素。
Aortic dissection (AD) is a life-threatening event that occurs when the intimal entry tear propagates and separates inner from outer layers of the aorta. Diameter, the current criterion for aneurysm repair, is far from ideal and additional evidence to optimize clinical decision would be extremely beneficial. Biomechanical investigation of the regional failure properties of aortic tissue is essential to understand and proactively prevent AD. We previously studied biaxial mechanical properties of healthy human aorta. In this study, we investigated the regional failure properties of healthy human ascending aorta (AscAo) including sinuses of Valsalva (SOV), and sinotubular junction (STJ). A total of 430 intact tissue samples were harvested from 19 healthy donors whose hearts were excluded from heart transplantation. The donors had mean age of 51±11.7 years and nearly equal gender distribution. Samples were excised from aortic regions and subregions at defined locations. Tissue strips were subjected to either biaxial or uniaxial failure testing. Wall thickness varied regionally being thickest at AscAo (2.08±0.66mm) and thinnest at SOV (1.46±0.31mm). Biaxial testing demonstrated hyperplastic behavior of aortic tissues. Posterior and lateral STJ subregions were found to be stiffer than anterior and medial subregions in both circumferential and longitudinal directions. Failure stresses were significantly higher in the circumferential than longitudinal directions in each subregion of AscAo, STJ, and SOV. Longitudinal failure stresses were significantly greater in AscAo than those in STJ or SOV. Longitudinal failure stresses in AscAo were much smaller anteriorly than posteriorly, and medially than laterally. The finding of weakest region at the sinotubular junction along the longitudinal direction corroborates clinical observations of that region being commonly involved as the initial site of intimal tear in aortic dissections. Failure stretch ratios correlated to elastic modulus at each region. Furthermore, strong correlation was seen between STJ failure stresses and elastic modulus at physiological pressure along both circumferential and longitudinal directions. Correlating in-vivo aortic elastic modulus based on in-vivo imaging with experimentally determined elastic modulus at physiological pressure and failure stresses may potentially provide valuable information regarding aortic wall strength. Better understanding of aortic biomechanics in normal physiologic and aneurysmal pathologic states may aid in determining risk factors for predicting dissection in patient-specific fashion.
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影响因子：
3.4
作者：
Azadani, Ali N.;Chitsaz, Sam;Tseng, Elaine E.
通讯作者：
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作者：
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影响因子：
5.4
作者：
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Ouzounian M