A cohort study of dysmenorrhea and risk of low birth weight
A cohort study of dysmenorrhea and risk of low birth weight
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痛经与低出生体重风险的队列研究
DOI：
10.1080/14767058.2021.1914581
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Huang D
中科院分区：
文献类型：
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作者：
Feng B;Li H;Peng Y;Jiang Q;Wu Y;Liu S;Zeng X;Qiu X;Huang D
摘要目的对母体痛经病史与围产儿结局之间的关系知之甚少。这项研究的目的是调查母亲痛经史与低出生体重(LBW)的关系。方法2015-2018年在广西进行的前瞻性队列研究中招募了6,754名孕妇中国。在第一次产前检查中，通过包括视觉模拟评分(VAS)问题的问卷调查，获得有关痛经母亲史的信息。对混杂因素(婴儿性别、产妇年龄、产次、孕前体重指数(BMI)(kg/m2)、孕周、孕期饮酒、被动吸烟和职业状况)进行Logistic回归分析，评估母亲痛经史与LBW的关系。结果有痛经史的母亲生下低出生体重儿的可能性较大(调整后的优势比(OR)=1.44；95%可信区间(CI)：1.12，1.83)。在有痛经病史的妇女中，年龄29岁(调整后OR 1.46；95%CI 1.02，2.10)、经期(调整后OR 1.59，95%CI 1.12，2.25)、生女婴(调整后OR=1.53，95%CI=1.11，2.11)的女性≥患低体重儿的风险较高。结论作为首次研究痛经史与LBW之间关系的队列研究，我们的研究表明痛经可能增加LBW的风险。
Abstract Objective Little is known about the association between maternal history of dysmenorrhea and perinatal outcomes. The aim of this study was to investigate the association between maternal history of dysmenorrhea and low birth weight (LBW). Methods A total of 6754 pregnant women were recruited from the ongoing prospective cohort study in Guangxi, China, in 2015–2018. Information on the maternal history of dysmenorrhea was obtained by questionnaires including visual analog scale (VAS) questions during the first antenatal care visit. The association of maternal history of dysmenorrhea and LBW was evaluated using logistic regression analyses adjusted for confounding factors (infant sex, maternal age, parity, pre-pregnancy body mass index (BMI) (kg/m2), gestational age, alcohol use during pregnancy, passive smoking, and occupational status). Results Mothers with a history of dysmenorrhea were more likely to give birth to LBW infants (adjusted odds ratio (OR)=1.44; 95% confidence interval (CI): 1.12, 1.83). Among women with a history of dysmenorrhea, women ≥29 years old (adjusted OR 1.46; 95% CI 1.02, 2.10), multiparous (adjusted OR 1.59, 95% CI 1.12, 2.25), and women gave birth to female infant (adjusted OR = 1.53, 95% CI = 1.11, 2.11) had a higher risk of LBW. Conclusions As the first cohort study to investigate the association between maternal history of dysmenorrhea and LBW, our study shows that dysmenorrhea may increase the risk of LBW.