Oxidative stress and DNA methylation in prostate cancer.
Oxidative stress and DNA methylation in prostate cancer.
复制标题
DOI：
10.1155/2010/302051
复制
发表时间：
2010
影响因子：
1.9
通讯作者：
Tindall DJ
中科院分区：
文献类型：
--
作者：
Donkena KV;Young CY;Tindall DJ
水果、蔬菜和其他食物对前列腺癌的保护作用可能是由于它们的抗氧化特性。在前列腺癌患者中观察到氧化应激/抗氧化状态的不平衡。前列腺癌患者的基因组氧化损伤与较高的脂质过氧化和较低的抗氧化水平有关。氧自由基与致癌作用的不同步骤有关，包括结构DNA损伤、表观遗传变化以及蛋白质和脂质改变。表观遗传学影响遗传调节、细胞分化、胚胎学、衰老、癌症和其他疾病。DNA甲基化可能是研究最广泛的表观遗传修饰，它在基因表达和染色质结构的调节中发挥着重要作用，与组蛋白修饰和其他染色质相关蛋白相关。本文综述了氧化应激与DNA甲基化的相互作用、DNA甲基化在基因表达调控中的变化、改变生活方式预防前列腺癌、DNA甲基化作为前列腺癌的生物标志物、检测甲基化的方法以及DNA甲基化抑制剂在表观遗传学治疗中的临床应用。
The protective effects of fruits, vegetables, and other foods on prostate cancer may be due to their antioxidant properties. An imbalance in the oxidative stress/antioxidant status is observed in prostate cancer patients. Genome oxidative damage in prostate cancer patients is associated with higher lipid peroxidation and lower antioxidant levels. Oxygen radicals are associated with different steps of carcinogenesis, including structural DNA damage, epigenetic changes, and protein and lipid alterations. Epigenetics affects genetic regulation, cellular differentiation, embryology, aging, cancer, and other diseases. DNA methylation is perhaps the most extensively studied epigenetic modification, which plays an important role in the regulation of gene expression and chromatin architecture, in association with histone modification and other chromatin-associated proteins. This review will provide a broad overview of the interplay of oxidative stress and DNA methylation, DNA methylation changes in regulation of gene expression, lifestyle changes for prostate cancer prevention, DNA methylation as biomarkers for prostate cancer, methods for detection of methylation, and clinical application of DNA methylation inhibitors for epigenetic therapy.