Decreased thermal niche breadth as a trade-off of antibiotic resistance.
Decreased thermal niche breadth as a trade-off of antibiotic resistance.
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热生态位宽度的减少是抗生素耐药性的权衡。
DOI：
10.1038/s41396-022-01235-6
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发表时间：
2022-07
期刊：
影响因子：
11
通讯作者：
Baym, Michael
中科院分区：
文献类型：
--
作者：
Herren, Cristina M.;Baym, Michael
进化理论预测，包括抗生素抗性在内的适应性变化应该伴随着相关的适应性成本;然而，许多抗性突变似乎与这一预测相矛盾，因为它们不会引起生长率赤字。然而，大多数比较敏感和耐药菌株的生长测定都是在狭窄的环境条件下进行的，这并不能反映病原菌在引起感染时可能遇到的各种环境。我们假设，生态位宽度的减少（定义为在多种环境中生长的减少）可能是抗生素耐药性的代价。具体来说，我们测试是否氯霉素耐药大肠杆菌在新的热条件下引起不成比例的增长赤字。在这里，我们表明，氯霉素耐药细菌有更大的健身成本在新的温度比他们的抗生素敏感的祖先。在几种情况下，我们观察到在历史温度下生长速率没有阻力成本，但在更高和更低的温度下生长减少。这些结果在各种抗性遗传机制中是一致的。因此，我们建议，减少热生态位宽度是一个记录不足的健身成本的抗生素耐药性。此外，这些结果表明，随着环境的变化，抗生素耐药性的成本迅速变化;这些依赖于环境的耐药性成本应该选择快速获得和丧失耐药性作为进化策略。
Evolutionary theory predicts that adaptations, including antibiotic resistance, should come with associated fitness costs; yet, many resistance mutations seemingly contradict this prediction by inducing no growth rate deficit. However, most growth assays comparing sensitive and resistant strains have been performed under a narrow range of environmental conditions, which do not reflect the variety of contexts that a pathogenic bacterium might encounter when causing infection. We hypothesized that reduced niche breadth, defined as diminished growth across a diversity of environments, can be a cost of antibiotic resistance. Specifically, we test whether chloramphenicol-resistant Escherichia coli incur disproportionate growth deficits in novel thermal conditions. Here we show that chloramphenicol-resistant bacteria have greater fitness costs at novel temperatures than their antibiotic-sensitive ancestors. In several cases, we observed no resistance cost in growth rate at the historic temperature but saw diminished growth at warmer and colder temperatures. These results were consistent across various genetic mechanisms of resistance. Thus, we propose that decreased thermal niche breadth is an under-documented fitness cost of antibiotic resistance. Furthermore, these results demonstrate that the cost of antibiotic resistance shifts rapidly as the environment changes; these context-dependent resistance costs should select for the rapid gain and loss of resistance as an evolutionary strategy.
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影响因子：
7.7
作者：
Kinsler G;Geiler-Samerotte K;Petrov DA
通讯作者：
Petrov DA
影响因子：
6.7
作者：
Gullberg E;Cao S;Berg OG;Ilbäck C;Sandegren L;Hughes D;Andersson DI
通讯作者：
Andersson DI
DOI：
10.1073/pnas.1000041107
发表时间：
2010-02-23
影响因子：
11.1
作者：
Helaine, Sophie;Thompson, Jessica A.;Holden, David W.
通讯作者：
Holden, David W.
影响因子：
11
作者：
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通讯作者：
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影响因子：
3.7
作者：
Mondal S;Pathak BK;Ray S;Barat C
通讯作者：
Barat C