Relationship between Gap Size and Dentine Secondary Caries Formation Assessed in a Microcosm Biofilm Model
Relationship between Gap Size and Dentine Secondary Caries Formation Assessed in a Microcosm Biofilm Model
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DOI：
10.1159/000209341
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发表时间：
2009-01-01
期刊：
影响因子：
4.2
通讯作者：
ten Cate, J. M.
中科院分区：
文献类型：
--
作者：
Cenci, M. S.;Pereira-Cenci, T.;ten Cate, J. M.
继发性龋可以在牙齿修复界面发展，这取决于间隙的存在及其大小，但这一过程可以被氟化物抑制。本研究的目的是评估间隙大小和牙本质继发龋的关系，邻近复合树脂（CR）或玻璃离子（GI）的牙本质继发龋，使用一个微宇宙的生物膜模型中的恒定深度的薄膜发酵罐（CDFF）。将用CR（Z250）或GI（Vitremer）修复的牙本质盘安装在CDFF上，间隙大小为0、50、100、180或250 μ m。在恢复的盘上形成微宇宙生物膜，并且每天经受8个脉冲的10%蔗糖溶液。第18天，用横向显微X线照相术测定牙本质矿物质损失和牙本质缺损周围的病变深度。间隙大小对矿物质丢失（p = 0.449）或病变深度（p = 0.328）的影响总体上无统计学显著性，但发现CR附近的矿物质丢失和病变深度大于GI（p < 0.001）。然而，斯皮尔曼相关性表明，CR的矿物质损失和病变深度随间隙大小而增加（p < 0.001），但GI则不随间隙大小而增加（p > 0.05）。研究结果支持这样的结论，即从GI释放的氟化物抑制牙本质脱矿邻近的牙本质脱矿，无论间隙宽度。版权所有（C）2009 S. Karger AG，巴塞尔
Secondary caries can develop at the tooth-restoration interface, depending on the presence of a gap and its size, but this process could be inhibited by fluoride. The aim of this study was to assess the relationship between gap size and dentine secondary caries adjacent to composite resin (CR) or glass ionomer (GI) restorations, using a microcosm biofilm model in a constant depth film fermentor (CDFF). Dentine discs restored with CR (Z250) or GI (Vitremer) with gap sizes of 0, 50, 100, 180 or 250 mu m were mounted on the CDFF. Microcosm biofilms were formed on the restored discs and daily subjected to 8 pulses of 10% sucrose solution. On the 18th day, dentine mineral loss and lesion depth around the restorations were determined by transverse microradiography. The effect of gap size was overall not statistically significant either with regard to mineral loss (p = 0.449) or lesion depth (p = 0.328), but greater mineral loss and lesion depth were found adjacent to CR than to GI (p < 0.001). However, Spearman correlation showed that mineral loss and lesion depth increased with gap size for CR (p < 0.001) but not for GI (p > 0.05). The findings support the conclusion that fluoride released from GI inhibits dentine demineralization adjacent to restorations, irrespective of gap width. Copyright (C) 2009 S. Karger AG, Basel