NORMAL CAFFEINE CONSUMPTION - INFLUENCE ON THERMOGENESIS AND DAILY ENERGY-EXPENDITURE IN LEAN AND POSTOBESE HUMAN VOLUNTEERS
NORMAL CAFFEINE CONSUMPTION - INFLUENCE ON THERMOGENESIS AND DAILY ENERGY-EXPENDITURE IN LEAN AND POSTOBESE HUMAN VOLUNTEERS
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DOI：
10.1093/ajcn/49.1.44
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发表时间：
1989-01-01
影响因子：
7.1
通讯作者：
MILLER, DS
中科院分区：
文献类型：
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作者：
DULLOO, AG;GEISSLER, CA;MILLER, DS
单剂量口服100毫克咖啡因使瘦身志愿者和肥胖后志愿者的静息代谢率在150分钟内增加了3-4%(p<；0.02)，并改善了肥胖后受试者因饮食缺陷而导致的产热现象。室内呼吸仪中能量消耗(EE)的测量表明，在12小时的白天期间，每隔2小时重复服用咖啡因(100毫克)，两组受试者的EE在此期间增加了8-11%(p<；0.01)，但对随后12小时的夜间EE没有影响。净效应是瘦身志愿者和肥胖后受试者的每日EE显著增加(p<；0.02)，分别为150千卡和79千卡。通常剂量的咖啡因可以对能量平衡产生重大影响，并可能促进肥胖症治疗中的生热作用。
Single-dose oral administration of 100 mg caffeine increased the resting metabolic rat of both lean and postobese human volunteers by 3-4% (p < 0.02) over 150 min and improved the defective diet-induced thermogenesis observed in the postobese subjects. Measurements of energy expenditure (EE) in a room respirometer indicate that repeated caffeine administration (100 mg) at 2-h intervals over a 12-h day period increased the EE of both subject groups 8-11% (p < 0.01) during that period but had no influence on the subsequent 12-h night EE. The net effect was a significant increase (p < 0.02) in daily EE of 150 kcal in the lean volunteers and 79 kcal in the postobese subjects. Caffeine at commonly consumed doses can have a significant influence on energy balance and may promote thermogenesis in the treatment of obesity.