The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues
The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues
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DOI：
10.1002/dvdy.21399
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发表时间：
2008-01-01
影响因子：
2.5
通讯作者：
Schreiber, Valerie
中科院分区：
文献类型：
--
作者：
Hakme, Antoinette;Huber, Aline;Schreiber, Valerie
大分子PARP-9和PARP-14是含有聚腺苷二磷酸核糖聚合酶的大分子结构域，参与免疫调节细胞因子的转录调控。它们的基因位于相同的位置(16B3)，PARP-9基因头对头地位于一起，并与编码其伙伴Bbap的基因共享其启动子。在这里，我们提供了PARP-9，PARP-14和Bbap在小鼠发育和成年过程中的表达的详细分析。PARP-9受发育调节，在胸腺、脑和肠道的特定区域显著表达。在成人中，胸腺和肠道中保持着最高的表达。PARP-14的表达较弱，主要在发育期间和成年期的胸腺。此外，我们发现Bbap在发育过程中和成年小鼠中基本上与PARP-9共表达。然而，在发育中的大脑和肠道中检测到的不同水平的转录本表明，Bbap和PARP-9既表现出共同的组织特异性调控，也表现出独立的组织特异性调控。
The macroPARPs Parp-9 and Parp-14 are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines. Their genes reside in the same locus (16B3), and the Parp-9 gene lies head-to-head and shares its promoter with the gene encoding its partner, Bbap. Here, we provide a detailed analysis of Parp-9, Parp-14, and Bbap expression during mouse development and adulthood. Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut. In adults, highest expression is maintained in the thymus and intestine. Parp-14 is more weakly expressed, mainly in the thymus during development and in adulthood. In addition, we show that Bbap is essentially coexpressed with Parp-9 during development and in adult mouse. However, the different levels of their transcripts detected in the developing brain and gut suggest that Bbap and Parp-9 display both common and independent tissue-specific regulations.