Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual Contrast T1- and T2-Weighted Magnetic Resonance Imaging
Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual Contrast T1- and T2-Weighted Magnetic Resonance Imaging
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DOI：
10.1021/bc900424u
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发表时间：
2010-03-01
影响因子：
4.7
通讯作者：
Park, Tae Gwan
中科院分区：
文献类型：
--
作者：
Bae, Ki Hyun;Kim, Young Beom;Park, Tae Gwan
采用生物启发的方法合成了Gd标记的磁性纳米颗粒(GMNPs)，并将其用作T-1和T-2加权磁共振成像的双重造影剂。利用贻贝衍生的粘附性基团3，4-二羟基-L-苯丙氨酸(DOPA)作为坚固锚，在氧化铁纳米颗粒表面形成聚乙二醇链和多巴胺分子的混合层。Gd离子随后在多巴胺分子的远端被络合，该分子被预先官能化为Gd的螯合配体。所得GMNPs在水溶液中表现出较高的分散稳定性。磁铁矿纳米晶的晶体结构和超顺磁性也在T-1和T-2加权磁共振成像的g-a凹坑的络合后保持不变。
Gadolinium-labeled magnetite nanoparticles (GMNPs) were synthesized via a bioinspired manner 10 use as dual contrast agents for T-1- and T-2-weighted magnetic resonance imaging. A mussel-derived adhesive moiety, 3,4-dihydroxy-L-phenylalanine (DOPA), was utilized as a robust anchor to form a mixed layer of poly(ethylene glycol) (PEG) chains and dopamine molecules on the surface of iron oxide nanoparticlcs. Gadolinium ions were subsequently complexed at the distal end of the dopamine molecules that were prefunctionalized with a chelating ligand for gadolinium. The resultant GMNPs exhibited high dispersion stability in aqueous Solution. Crystal structure and superparamagnetic properties of magnetite nanocrystals were also maintained after the complexation of g a pits for T-1 and T-2-weighted magnetic resonance imaging was demonstrated by conducting in vitro and in vivo imaging and relaxivity measurements.