Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
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DOI：
10.1038/s41590-020-00832-x
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发表时间：
2020-11-18
影响因子：
30.5
通讯作者：
Mantovani, Alberto
中科院分区：
文献类型：
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作者：
Brunetta, Enrico;Folci, Marco;Mantovani, Alberto
Mantovani和他的同事报告说，在患有严重新冠肺炎的患者中，长五新PTX3的循环浓度升高。在这个队列中，早期检测到高PTX3浓度是降低存活率的有力预测因素。长五肽3(PTX3)是体液天然免疫的重要组成部分，参与对选定病原体的抵抗和炎症的调节(1-3)。本研究旨在评估PTX3在冠状病毒病2019(新冠肺炎)中的存在及其意义(4-7)。外周血单核细胞测序、单细胞生物信息学分析和肺组织免疫组织化学分析显示，新冠肺炎患者骨髓单核细胞和血管内皮细胞表达高水平的PTX3。96例新冠肺炎患者血浆甲状旁腺素3浓度升高。在多变量分析中，PTX3在新冠肺炎住院患者中成为28天死亡率的强大独立预测因子，优于传统的炎症标志物。PTX3丰度对死亡率的预后意义在第二个独立队列(54例患者)中得到证实。因此，循环和肺内粒单核细胞和内皮细胞是PTX3的主要来源，PTX3血浆浓度可以作为新冠肺炎患者短期死亡的独立强有力的预后指标。
Mantovani and colleagues report elevated circulating concentrations of the long pentraxin PTX3 in patients with severe COVID-19. Within this cohort, early detection of high PTX3 concentrations emerged as a strong predictor of decreased survival.Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation(1-3). The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)(4-7). RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.