Understanding Dorsoventral Topography Backwards and Forwards
Understanding Dorsoventral Topography Backwards and Forwards
复制标题
向后和向前了解背腹地形
DOI：
10.1016/s0896-6273(02)00797-3
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发表时间：
2002
期刊：
影响因子：
16.2
通讯作者：
C. Chien
中科院分区：
文献类型：
--
作者：
Andrew J. Pittman;C. Chien
视网膜轴突沿着两个正交的地形轴（前-后（A-P）和背-腹（D-V））投射到它们的中心目标沿着。虽然ephrin-A/EphA信号传导决定A-P拓扑，但关于沿沿着D-V轴引导轴突的分子机制知之甚少。Mann等和Hindges等在本期《神经元》上发表的两篇论文提供了正向和反向ephrin-B/EphB信号传导调节D-V地形图的证据。
Retinal axons project to their central targets along two orthogonal topographic axes, anterior-posterior (A-P) and dorsal-ventral (D-V). While ephrin-A/EphA signaling determines A-P topography, little has been known about the molecular mechanisms guiding axons along the D-V axis. Two papers by Mann et al. and Hindges et al. in this issue ofNeuronprovide evidence for both forward and reverse ephrin-B/EphB signaling in regulating D-V topography.