Early and late tuberculosis risks among close contacts in Hong Kong.
Early and late tuberculosis risks among close contacts in Hong Kong.
复制标题
香港密切接触者的早期和晚期结核病风险。
DOI：
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复制
发表时间：
2008
期刊：
影响因子：
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通讯作者：
E. Leung
中科院分区：
文献类型：
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作者：
M. Lee;C. Leung;K. Kam;M. Wong;M. Leung;C. Tam;E. Leung
设置
SETTING
Tuberculosis (TB) notification is a statutory requirement in Hong Kong, where contact investigations are performed by the Tuberculosis and Chest Service.
OBJECTIVES
1) To evaluate the risk of active TB in close contacts within 5 years, and 2) to identify risk factors associated with early and late development of active TB disease.
DESIGN
The characteristics of consecutive TB cases notified from 18 January to 17 April 2000 were collected together with those of their contacts. Contacts were prospectively followed up through the territory-wide TB notification registry for 5 years for the development of disease.
RESULTS
A total of 1537 index cases and 4661 close contacts were analysed. Screening found 31 (0.67%) active TB cases within a 3-month period, and another 58 (1.24%) cases presented subsequently. Index cases with cough or pulmonary cavities and diabetic contacts were independent risk factors of early cases (all P<0.05). Adjusted at risk index characteristics for late TB development included positive sputum smear (2.79, 95%CI 1.31-5.95) and family history of TB (4.26, 95%CI 2.01-9.03). Contact risk factors included diabetes mellitus (3.44, 95%CI 1.04-11.33) and institutionalisation (3.61, 95%CI 1.70-7.65).
CONCLUSION
Considerable TB risk remains after initial contact screening. A number of possible risk factors were identified.