Kinetics of dendritic cell activation:: impact on priming of TH1, TH2 and nonpolarized T cells
Kinetics of dendritic cell activation:: impact on priming of TH1, TH2 and nonpolarized T cells
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DOI：
10.1038/79758
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发表时间：
2000-10-01
影响因子：
30.5
通讯作者：
Sallusto, F
中科院分区：
文献类型：
--
作者：
Langenkamp, A;Messi, M;Sallusto, F
为了引发免疫应答，树突状细胞（DC）需要被激活以获得T细胞刺激能力。虽然有些刺激物可以触发白细胞介素12（IL-12）的产生，从而导致T辅助细胞1型（T（H）1）极化，但其他刺激物则不能这样做，而有利于T（H）2极化。我们发现，在脂多糖激活后，DC只能短暂地产生IL-12，并且对进一步的刺激变得不敏感。刺激后不久，DC引发强烈的T（H）1反应，而在稍后的时间点，相同的细胞优先引发T（H）2和非极化T细胞。这些发现表明，在免疫应答期间，淋巴结中的T细胞引发条件可能会发生变化，这表明了调节效应和记忆T细胞的另一种机制。
To prime immune responses, dendritic cells (DCs) need to be activated to acquire T cell stimulatory capacity. Although some stimuli trigger interleukin 12 (IL-12) production that leads to T helper cell type 1 (T(H)1) polarization, others fail to do so and favor T(H)2 polarization,We show that after activation by lipopolysaccharide, DCs produced IL-12 only transiently and became refractory to further stimulation,The exhaustion of cytokine production impacted the T cell polarizing process. Soon after stimulation DCs primed strong T(H)1 responses, whereas at later time points the same cells preferentially primed T(H)2 and nonpolarized T cells. These findings indicate that during an immune response, T cell priming conditions may change in the lymph nodes, suggesting another mechanism for the regulation of effector and memory T cells.