ASQ-3 scores are sensitive to small differences in age in a Peruvian infant population
ASQ-3 scores are sensitive to small differences in age in a Peruvian infant population
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DOI：
10.1111/cch.12469
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发表时间：
2017-07-01
影响因子：
1.9
通讯作者：
Llanos, F.
中科院分区：
文献类型：
--
作者：
Chong, K. C.;Zhou, V. L.;Llanos, F.
目的年龄与阶段量表第3版（ASQ-3）是一种国际公认的儿童发育迟缓筛查工具。然而，以前的研究表明，有资格采取相同的ASQ-3间隔的儿童之间的得分不同。本研究旨在确定年龄和ASQ-3评分之间的关系，每个screening interval.Methods这是一个基线探索性横断面研究的婴儿2岁以下的秘鲁社会计划库纳马斯评估。如果参与者居住在居民少于2 000人或家庭少于400户的地区，表明主要是农村人口，则将他们列入库纳马斯。对每例受试者给予适当的ASQ-3筛选间隔。根据每个2个月筛选时间窗内的年龄，将受试者分为4个2周时间顺序亚组，并在所有12个筛选间隔内汇总。采用Fisher精确检验、方差分析和Bonferonni事后检验比较年龄亚组之间的差异。进行线性回归，以评估ASQ-3评分和两个汇总和分类的年龄subgroup.Results共5850秘鲁婴儿在2013年进行了评估之间的关系。平均年龄为13 +/- 6.6个月，50.7%为男性，平均母亲教育为6.6 +/- 4.0年; 34.8%的婴儿发育不良，7.8%体重不足，0.9%消瘦，2%的ASQ-3间期分配的早产儿年龄调整后大于35天。平均总ASQ-3为42.2 +/- 8.2。ASQ-3在一个或多个发展领域中分配了49.6%的疑似延迟。在调整财富五分位数、母亲教育水平、婴儿营养状况和早产调整后，年龄亚组与ASQ-3总分仍显著相关（β = 1.8，CI：1.7-2.0，P < 0.001），ASQ-3分段评分（均P < 0.001），并与一个或多个提示疑似发育迟缓的评分呈负相关结论ASQ-3可能低估了儿童发育对年龄差异的敏感性。
Objective The Ages and Stages Questionnaires Edition 3 (ASQ-3) are a well-validated international screen for developmental delays in young children. However, previous studies demonstrate variable scores between children eligible to take the same ASQ-3 interval. This study aimed to determine a relationship between age and ASQ-3 score for each screening interval.Methods This was a baseline exploratory cross-sectional study of infants under 2 years old evaluated for the Peruvian social programme Cuna Mas. Participants were included in Cuna Mas if they lived in districts with fewer than 2000 inhabitants or 400 homes, indicating a predominantly rural population. The appropriate ASQ-3 screening interval was administered to each subject. Subjects were divided into four 2-week chronological subgroups based on age within each 2-month screening window and aggregated across all 12 screening intervals. Fisher's exact test, analysis of variance and Bonferonni post hoc test were used to compare differences between age subgroups. Linear regression was performed to assess the relationship between ASQ-3 score and both aggregated and disaggregated age subgroup.Results A total of 5850 Peruvian infants were evaluated in 2013. Mean age was 13 +/- 6.6 months, 50.7% were male and mean maternal education was 6.6 +/- 4.0 years; 34.8% infants were stunted, 7.8% were underweight, 0.9% were wasted and 2% had age adjusted greater than 35 days for prematurity for ASQ-3 interval assignment. Mean total ASQ-3 was 42.2 +/- 8.2. The ASQ-3 allocated 49.6% with suspected delay in one or more developmental areas. Before and after adjusting for wealth quintile, maternal education level, infant nutritional status and prematurity adjustment, age subgroup remained significantly associated with total ASQ-3 score (beta = 1.8, CI: 1.7-2.0, P < 0.001), sectional ASQ-3 score (all P < 0.001) and inversely associated with one or more scores indicating suspected developmental delay (P < 0.001).Conclusions The ASQ-3 may underestimate the sensitivity of child development to small differences in age in this population.