Supported lipid bilayer/carbon nanotube hybrids
Supported lipid bilayer/carbon nanotube hybrids
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DOI：
10.1038/nnano.2007.34
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发表时间：
2007-03-01
影响因子：
38.3
通讯作者：
McEuen, Paul L.
中科院分区：
文献类型：
--
作者：
Zhou, Xinjian;Moran-Mirabal, Jose M.;McEuen, Paul L.
碳纳米管晶体管联合收割机结合了分子尺度的尺寸和优异的电子性能，为化学和生物传感提供了独特的机会。在这里，我们在单壁碳纳米管晶体管上形成支持的脂质双层。我们首先研究的纳米管/支持的脂质双层结构的物理性质，使用荧光技术。脂质分子可以在纳米管中自由扩散，而膜结合蛋白（破伤风毒素）则将纳米管视为屏障。此外，屏障的大小取决于纳米管的直径-纳米管越大，扩散的障碍就越大。然后，我们证明检测蛋白质结合（链霉亲和素）的支持脂质双层使用的纳米管晶体管作为电荷传感器。该系统可以作为一个平台，以检查单分子与碳纳米管的相互作用，并有许多潜在的应用研究分子识别和其他生物过程发生在细胞膜上。
Carbon nanotube transistors combine molecular-scale dimensions with excellent electronic properties, offering unique opportunities for chemical and biological sensing. Here, we form supported lipid bilayers over single-walled carbon nanotube transistors. We first study the physical properties of the nanotube/supported lipid bilayer structure using fluorescence techniques. Whereas lipid molecules can diffuse freely across the nanotube, a membrane-bound protein (tetanus toxin) sees the nanotube as a barrier. Moreover, the size of the barrier depends on the diameter of the nanotube - with larger nanotubes presenting bigger obstacles to diffusion. We then demonstrate detection of protein binding (streptavidin) to the supported lipid bilayer using the nanotube transistor as a charge sensor. This system can be used as a platform to examine the interactions of single molecules with carbon nanotubes and has many potential applications for the study of molecular recognition and other biological processes occurring at cell membranes.