Stimuli-responsive microgels for the loading and release of functional compounds: Fundamental concepts and applications
Stimuli-responsive microgels for the loading and release of functional compounds: Fundamental concepts and applications
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DOI：
10.1016/j.polymer.2012.08.053
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发表时间：
2012-10-26
期刊：
影响因子：
4.6
通讯作者：
Landfester, Katharina
中科院分区：
文献类型：
--
作者：
Klinger, Daniel;Landfester, Katharina
刺激响应型微凝胶代表了一类非常有趣和独特的材料，因为它们表现出特殊的性质，这源于它们的胶体性质和内部网络结构的特殊组合。虽然这一迷人的特性已被用于各种不同的研究领域和应用，但成功开发所有这些不同材料的基本共同点是对各自的微凝胶进行精确设计，以调整其功能以适应特定的应用。尤其是关于功能化合物的输送，主要任务之一是将有效的装载过程与明确的释放曲线相结合。实现这一目标的一个基本要求是深刻理解这些材料特性的基本概念，以及这些基本模型对设计和制备这种具有量身定制特性的高功能材料的影响。因此，在这篇综述中，我们介绍了一些关于(可调节的)网络特征对载药和释放曲线的影响的重要基础研究，实现这些概念的基本合成概念，并重点介绍了用于载药和释放应用的刺激响应微凝胶的不同方法的几个例子。通过这一点，我们希望为读者提供一个广泛的概述设计标准和实用方法，以控制微凝胶的功能，以鼓励进一步发展这一材料科学领域中非常有趣的概念和材料。(C)2012爱思唯尔有限公司。保留所有权利。
Stimuli-responsive microgels represent a highly interesting and unique class of materials since they exhibit exceptional properties which stem from the particular combination of their colloidal nature with their internal network structure. While this fascinating characteristic feature has been exploited in various different research fields and applications, the essential commonality for the successful development of all those diverse materials is a precise design of the respective microgels to adjust their functionality to a specific application. Regarding the delivery of functional compounds in particular, one of the main tasks is to combine an efficient loading process with a well defined release profile. A basic requirement to achieve this goal is a profound understanding of the underlying concepts of these material's features and the impact of these basic models on the design and preparation of such highly functional materials exhibiting tailor-made properties. Therefore, in this review we present some of the important fundamental examinations on the influence of (tunable) network characteristics on loading and release profiles, basic synthetic concepts to realize these concepts and highlight several examples of different approaches to stimuli-responsive microgels for loading and release applications. By this, we wish to give the reader a broad overview of the design criteria and practical methodologies to control the functionality of microgels in order to encourage further development of highly interesting concepts and materials in this area of materials science. (c) 2012 Elsevier Ltd. All rights reserved.