Prenatal and postnatal ethanol exposure influences preweanling rats' behavioral and autonomic responding to ethanol odor
Prenatal and postnatal ethanol exposure influences preweanling rats' behavioral and autonomic responding to ethanol odor
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DOI：
10.1016/0741-8329(96)00027-4
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发表时间：
1996-07-01
期刊：
影响因子：
2.3
通讯作者：
Spear, N
中科院分区：
文献类型：
--
作者：
Chotro, MG;Kraebel, KS;Spear, N
具体的问题是如何产前和/或出生后的经验与乙醇影响心脏和行为反应的气味乙醇出生后第16天（PD）在每两个实验中，孕鼠给予乙醇或水在妊娠第17-20天。在PD 12时，后代暴露于三种条件之一：胃内给药暴露于同窝仔的乙醇，或不给药。实验1的结果表明，添加6%乙醇，产前间接接触乙醇，16日龄的狗在PD 12直接或间接接触乙醇时，对乙醇气味的反应比出生后未接触乙醇的狗更明显。在实验2中，其中使用较低的乙醇剂量出生后，出生前和出生后的乙醇暴露之间的相互作用进行了观察，也就是说，幼崽暴露于出生前和出生后的乙醇表现出最大的增加心率和最小的增加在响应乙醇气味的运动活动。在这两个expendments运动活动的增加，HR. The结果进行了讨论，在什么是学到的，产前和产后与乙醇的chemosensory属性。
The specific question was how prenatal and/or postnatal experience with ethanol influences cardiac and behavioral responses to the odor of ethanol on postnatal day (PD) 16 In each of two experiments, pregnant rats were given ethanol or water on gestational days 17-20. Offspring were exposed on PD12 to one of three conditions: intragastric administration of exposure to ethanol from littermates, or no treatment. Results of Experiment 1 indicated that, regard6% ethanol, indirect less of prenatal ethanol exposure, 16-day-olds exposed on PD12 either directly or indirectly to ethanol expressed a greater increase in HR in response to ethanol odor than pups not postnatally exposed to ethanol. In Experiment 2, in which a lower ethanol dose was used postnatally, an interaction between pre- and postnatal ethanol exposure was observed; that is, pups exposed pre- and postnatally to ethanol showed the greatest increases in HR and the smallest increases in motor activity in response to ethanol odor. In both expenments motor activity was dissociated from increases in HR. The results are discussed in terms of what is learned, prenatally and postnatally in association with the chemosensory properties of ethanol.