IN-VIVO BIOGENIC-AMINE EFFLUX IN MEDIAL PREFRONTAL CORTEX WITH IMIPRAMINE, FLUOXETINE, AND FLUVOXAMINE
IN-VIVO BIOGENIC-AMINE EFFLUX IN MEDIAL PREFRONTAL CORTEX WITH IMIPRAMINE, FLUOXETINE, AND FLUVOXAMINE
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DOI：
10.1002/syn.890180404
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发表时间：
1994-12-01
期刊：
影响因子：
2.3
通讯作者：
PETTY, F
中科院分区：
文献类型：
--
作者：
JORDAN, S;KRAMER, GL;PETTY, F
在体内脑微透析被用来确定标准的三环类抗抑郁药丙咪嗪和两种选择性5-羟色胺再摄取抑制剂（SSRIs）抗抑郁药，氟西汀和氟伏沙明，对细胞外水平的去甲肾上腺素（NE），多巴胺（DA），和5-羟色胺（5-HT）在大鼠内侧前额叶皮层的影响。当给予腹腔注射（IF），丙咪嗪增加NE在微透析灌流液中，并升高DA和5-HT在较小程度上。在IF氟西汀后检测到DA和5-HT的类似剂量依赖性增加，尽管NE受影响较小。与此相反，IP氟伏沙明产生的基础NE或DA没有变化，虽然在5-HT的大幅度增加发生在一个中间剂量。当直接给药到皮层，所有三种抗抑郁药增加5-HT相同的量在剂量依赖性的方式。皮质内丙咪嗪和氟西汀增加NE，氟西汀和氟伏沙明都增加DA，氟西汀在较低浓度下这样做。这些数据表明，SSRIs在体内对5-羟色胺不是完全选择性的。(C)1994 Wiley-Liss，Inc.
In vivo brain microdialysis was used to determine the effects of the standard tricyclic antidepressant imipramine and the two selective serotonin reuptake inhibitors (SSRIs) antidepressants, fluoxetine and fluvoxamine, on extracellular levels of norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in rat medial prefrontal cortex. When given intraperitoneally (IF), imipramine increased NE in the microdialysis perfusate, and elevated DA and 5-HT to a lesser extent. Similar dose-dependent increases in DA and 5-HT were detected after IF fluoxetine, although NE was less affected. In contrast, IP fluvoxamine produced no change in basal NE nor DA, although a large increase in 5-HT occurred at an intermediate dose. When administered directly into cortex, all three antidepressants increased 5-HT by the same amount in a dose-dependent fashion. Intracortical imipramine and fluoxetine increased NE, and fluoxetine and fluvoxamine both increased DA, with fluoxetine doing so at a lower concentration. These data suggest that the SSRIs are not entirely selective for serotonin in vivo. (C) 1994 Wiley-Liss, Inc.