Trabecular bone microstructure and mineral density in human residual ridge at various intervals over a long period after tooth extraction
Trabecular bone microstructure and mineral density in human residual ridge at various intervals over a long period after tooth extraction
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DOI：
10.1111/cid.12591
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发表时间：
2018-06-01
影响因子：
3.6
通讯作者：
Ejiri，Sadakazu
中科院分区：
文献类型：
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作者：
Tanaka，Mikako;Yamashita-Mikami，Emi;Ejiri，Sadakazu
背景人类拔牙槽内骨小梁微结构的长期变化尚未被研究。目的检测拔牙后不同时间间隔的人残牙槽骨小梁微结构，以确定骨重建活动是否能够达到相对稳定点以及何时达到该点。材料与方法从残牙槽的下磨牙或前磨牙区域获取44个骨活检标本。拔牙后时间范围为 1.6 至 360 个月。使用微型计算机断层扫描和三维骨形态测量以及组织学分析对样品进行分析。将骨小梁参数与拔牙后时间作图，并进行逐步分段线性回归分析，以确定这些参数在哪些时间点增加或减少。结果使用分段线性回归，在拔牙后 7 至 12 个月之间，大多数骨小梁参数都发现了“拐点”。在残余牙槽嵴样本中，编织小梁结构变得成熟，由具有足够骨密度的厚层状小梁组成，在动态骨重塑下直至拔牙后第7至12个月。此后成熟的网络结构保持稳定，重塑活性较低。结论人体拔牙后残牙槽骨小梁结构的骨重塑有一个稳定期。
BackgroundLong‐term changes of trabecular microstructure in human tooth extraction socket have not been investigated.PurposeTo examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can attain points of relative stability and when such points are reached.Materials and MethodsForty‐four bone biopsy specimens were obtained from lower molar or premolar regions of residual ridges. Postextraction times ranged from 1.6 to 360 months. Samples were analyzed using micro‐computed tomography and three‐dimensional bone morphometry with histological analyses. Trabecular bone parameters were plotted against postextraction times, and a stepwise piecewise linear regression analysis was performed to determine at which points of time these parameters either increased or decreased.ResultsUsing piecewise linear regression, “inflection points” were found in most trabecular bone parameters between 7 and 12 months postextraction. Among the residual ridge samples, woven trabecular structure became mature, consisting of thick lamellar trabeculae with sufficient bone density, under dynamic bone remodeling until the 7th to 12th month post‐tooth extraction. After this period, the mature network structure remained stable with low remodeling activity.ConclusionBone remodeling of trabecular structure in human residual ridge after tooth extraction had a stabilization period.