Comparative study of placental -microglobulin-1, insulin-like growth factor binding protein-1 and nitrazine test to diagnose premature rupture of membranes: A randomized controlled trial
Comparative study of placental -microglobulin-1, insulin-like growth factor binding protein-1 and nitrazine test to diagnose premature rupture of membranes: A randomized controlled trial
复制标题
DOI：
10.1111/jog.12381
复制
发表时间：
2014-06-01
影响因子：
1.6
通讯作者：
Jia, Xiao-yan
中科院分区：
文献类型：
--
作者：
Liang, De-ku;Qi, Hong-bo;Jia, Xiao-yan
目的比较胎盘微球蛋白-1（PAMG-1）、胰岛素样生长因子结合蛋白-1（IGFBP-1）和硝嗪试验诊断胎膜早破的准确性。材料和方法共有120名孕妇之间的11和42周的胎膜破裂的体征/症状符合我们的研究。这些妇女进行了评估与PAMG-1，IGFBP-1，和硝嗪测试。结果PAMG-1、IGFBP-1和Nitrazine检测的敏感性、特异性、阳性预测值和阴性预测值分别为100%、100%、100%和100%; 93.33%、98.89%、96.55%和97.80%; 93.33%、94.44%、84.85%和97.7%。分别PAMG-1试验与硝嗪试验比较，阳性符合率为84.85%，阴性符合率为97.70%，总符合率为94.17%，kappa值为0.85。PAMG-1试验与IGFBP-1试验比较，阳性符合率、阴性符合率和总符合率分别为96.55%、97.80%和97.50%，kappa值为0.93。结论PAMG-1检测是诊断胎膜早破最准确的方法，其敏感性、特异性、阳性预测值和阴性预测值均最高。
Aim The aim of this study was to compare the accuracy of placental -microglobulin-1 (PAMG-1), insulin-like growth factor binding protein-1 (IGFBP-1) and nitrazine test to diagnose premature rupture of membranes. Material and Methods A total of 120 pregnant women between 11 and 42 weeks with signs/symptoms of membrane rupture were eligible for our study. These women were evaluated with the PAMG-1, IGFBP-1, and nitrazine tests. Results In the 120 women, the sensitivity, specificity, positive predictive value, and negative predictive value of PAMG-1, IGFBP-1 and nitrazine test were 100%, 100%, 100%, and 100%, 93.33%, 98.89%, 96.55% and 97.80%, and 93.33%, 94.44%, 84.85%, and 97.7%, respectively. In a comparison of the PAMG-1 test and the nitrazine test, positive coincidence rate was 84.85%, negative coincidence rate was 97.70%, total coincidence rate was 94.17%, and kappavalue was 0.85. In a comparison of the PAMG-1 test and the IGFBP-1 test, the positive coincidence rate, negative coincidence rate and total coincidence rate were 96.55%, 97.80%, and 97.50%, and kappavalue was 0.93. Conclusion PAMG-1 assay was the most accurate method to diagnose premature rupture of membranes with the highest sensitivity, specificity, positive predictive value and negative predictive value.