Chapter two--Adenovirus strategies for tissue-specific targeting.
Chapter two--Adenovirus strategies for tissue-specific targeting.
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DOI：
10.1016/b978-0-12-398342-8.00002-1
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发表时间：
2012
影响因子：
--
通讯作者：
Curiel, David T.
中科院分区：
文献类型：
--
作者：
Beatty, Matthew S.;Curiel, David T.
癌症基因治疗方法从基于分子的治疗方法的利用中受益匪浅。其中，基于腺病毒的干预措施作为肿瘤靶向治疗的平台有很大的希望。然而，这种进展的障碍是在多种癌症类型上缺乏天然腺病毒受体表达。因此，任何基于腺病毒的癌症治疗都必须考虑将载体重新靶向非天然细胞表面受体。基于在天然腺病毒生物学中获得的知识，已经出现了几种转导重靶向腺病毒的策略。在此，我们描述了生物学障碍，以及利用腺病毒转导靶向的策略，涵盖了基于衔接子和基于遗传操作的靶向进展。此外，我们还讨论了这些靶向策略最近的翻译成临床环境。
Cancer gene therapy approaches have benefited greatly from the utilization of molecular-based therapeutics. Of these, adenovirus-based interventions hold much promise as a platform for targeted therapeutic delivery to tumors. However, a barrier to this progression is the lack of native adenovirus receptor expression on a variety of cancer types. As such, any adenovirus-based cancer therapy must take into consideration retargeting the vector to nonnative cellular surface receptors. Predicated upon the knowledge gained in native adenovirus biology, several strategies to transductionally retarget adenovirus have emerged. Herein, we describe the biological hurdles as well as strategies utilized in adenovirus transductional targeting, covering the progress of both adapter-based and genetic manipulation-based targeting. Additionally, we discuss recent translation of these targeting strategies into a clinical setting.