The influence of migraine and female hormones on capsaicin-induced dermal blood flow
The influence of migraine and female hormones on capsaicin-induced dermal blood flow
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DOI：
10.1177/0333102416668659
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发表时间：
2017-10-01
期刊：
影响因子：
4.9
通讯作者：
de Hoon, Jan
中科院分区：
文献类型：
--
作者：
Ibrahimi, Khatera;Vermeersch, Steve;de Hoon, Jan
背景：偏头痛在女性中比男性更常见，其发生与女性性激素的变化有关。降钙素基因相关肽 (CGRP) 在偏头痛中起关键作用，女性性激素的变化可能会影响 CGRP 敏感性和/或产生。目的：研究重复性、性别差异、月经周期和偏头痛对 CGRP 依赖性真皮血流变化 (DBF) 的影响。方法：局部应用 300 或将 1000 μg 辣椒素涂抹在健康受试者和偏头痛患者的前臂上。结果：在健康男性中，DBF 反应不随时间变化，与男性偏头痛患者的 DBF 相当。在健康女性中，与分泌后期相比，辣椒素诱导的对两种剂量辣椒素的 DBF 反应在月经期间均较高（p < 0.05）；女性偏头痛患者不存在这种月经周期依赖性。与健康受试者相比，女性偏头痛患者在月经期间和分泌后期均表现出较高的 DBF 反应（p < 0.05）。结论：在健康女性的月经期间观察到辣椒素诱导的 CGRP 介导的 DBF 反应增加，但在女性偏头痛患者中，这种增加的反应不受月经周期的影响。
Background: Migraine is much more common in females than in males, and occurrence is associated with changes in female sex hormones. Calcitonin gene-related peptide (CGRP) plays a key role in migraine, and variations in female sex hormones may affect CGRP sensitivity and/or production.Objectives: Investigate repeatability, gender differences, influence of the menstrual cycle and of migraine on CGRP-dependent changes in dermal blood flow (DBF).Methods: CGRP-dependent increases in DBF were assessed using laser Doppler perfusion imaging after topical application of 300 or 1000 mu g capsaicin on the forearm of healthy subjects and migraine patients.Results: In healthy males, DBF response did not vary over time and was comparable with DBF in male migraineurs. In healthy females, capsaicin-induced DBF responses to both doses of capsaicin were higher during menstruation compared to the late-secretory phase (p < 0.05); this menstrual cycle dependence was absent in female migraine patients. Compared to healthy subjects, female migraineurs displayed a higher DBF response both during menstruation and during the late-secretory phase (p < 0.05).Conclusions: An increased capsaicin-induced, CGRP-mediated DBF response was observed during menstruation in healthy women, but in female migraine patients this increased response was not affected by the menstrual cycle.