25-year prostate cancer control and survival outcomes: A 40-year radical prostatectomy single institution series
25-year prostate cancer control and survival outcomes: A 40-year radical prostatectomy single institution series
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DOI：
10.1016/j.juro.2006.03.094
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发表时间：
2006-08-01
影响因子：
6.6
通讯作者：
Karakiewicz, Pierre I.
中科院分区：
文献类型：
--
作者：
Porter, Christopher R.;Kodama, Koichi;Karakiewicz, Pierre I.
目的：我们报告了25年的癌症控制和根治性直肠癌切除术后的患者在一个单一的中心系列治疗在40年的periods.Materials和方法：1954年和1994年之间，787例连续进行根治性直肠癌切除术在弗吉尼亚梅森医学中心在西雅图，华盛顿。测定前列腺癌特异性、总体、前列腺特异性抗原无进展、局部和远处无进展生存期的Kaplan-Meier 25年概率。多变量考克斯回归模型处理前列腺癌特异性死亡率。前列腺癌特异性生存期、总生存期、前列腺特异性抗原无进展生存期、局部和远处无进展生存期范围为99.0%-81.5%、93.5%-19.3%、84.8%-54.5%、95.3%-87.8%和95.9%-78.2%，分别在单因素分析中，病理分期、手术切缘状态、病理Gleason总和、激素治疗和放射治疗是前列腺癌特异性死亡率的统计学显著预测因素（均P
Purpose: We report on 25-year cancer control and survival outcomes after radical prostatectomy in a single center series of patients treated during a 40-year period.Materials and Methods: Between 1954 and 1994, 787 consecutive patients underwent radical prostatectomy at Virginia Mason Medical Center in Seattle, Washington. Kaplan-Meier 25-year probabilities of prostate cancer specific, overall, prostate specific antigen progression-free, local and distant progression-free survival were determined. Multivariate Cox regression models addressed prostate cancer specific mortality.Results: Prostate cancer specific survival, overall survival, prostate specific antigen progression-free survival, local and distant progression-free survival ranged from 99.0% to 81.5%, 93.5% to 19.3%, 84.8% to 54.5%, 95.3% to 87.8% and 95.9% to 78.2%, respectively. In univariate analyses pathological stage, surgical margin status, pathological Gleason sum, delivery of hormonal therapy and radiotherapy represented statistically significant predictors of prostate cancer specific mortality (all P