Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.
Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.
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别嘌呤醇可减少缺血再灌注犬心脏中的梗塞面积。
DOI：
10.1161/01.cir.73.3.518
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发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
Lucchesi,BR
中科院分区：
文献类型：
--
作者：
Werns,SW;Shea,MJ;Mitsos,SE;Dysko,RC;Fantone,JC;Schork,MA;Abrams,GD;Pitt,B;Lucchesi,BR
本研究的目的是评估别嘌呤醇在犬心肌梗塞制剂中的作用。狗的左冠状动脉回旋支闭塞90分钟，然后再灌注6小时。研究了三组：(1)对照组，(2)狗在闭塞前18小时接受25mg/kg别嘌呤醇，在闭塞前5分钟接受50mg/kg别嘌呤醇，(3)狗在再灌注前15分钟开始接受上述别嘌呤醇加上5mg/kg超氧化物歧化酶1小时以上。梗塞面积以占危险区域的百分比表示，对照组为 40 +/- 4，别嘌呤醇组为 22 +/- 5（与对照组相比，p 小于 0.05），别嘌呤醇加超氧化物歧化酶组为 17 +/- 4（与对照组相比，p 小于 0.05）。梗塞面积的差异并不是由于心肌氧供应或需求的差异造成的。别嘌呤醇治疗不会改变中性粒细胞超氧阴离子的产生。结果表明，心肌黄嘌呤氧化酶可能产生氧自由基，在缺血和再灌注引起的心肌损伤中发挥作用。
This study was performed to assess the effect of allopurinol in a canine preparation of myocardial infarction. Dogs underwent occlusion of the left circumflex coronary artery for 90 min, followed by reperfusion for 6 hr. Three groups were studied: (1) control, (2) dogs receiving 25 mg/kg allopurinol 18 hr before occlusion and 50 mg/kg 5 min before occlusion, and (3) dogs receiving allopurinol as above plus 5 mg/kg superoxide dismutase over 1 hr beginning 15 min before reperfusion. Infarct size expressed as a percentage of the area at risk was 40 +/- 4 in the control group, 22 +/- 5 in the allopurinol group (p less than .05 vs control), and 17 +/- 4 in the allopurinol plus superoxide dismutase group (p less than .05 vs control). The differences in infarct size were not due to differences in myocardial oxygen supply or demand. Neutrophil superoxide anion production was not altered by allopurinol treatment. The results suggest that myocardial xanthine oxidase may generate oxygen radicals that play a role in myocardial injury due to ischemia and reperfusion.