IL-32γ promotes integrin αvβ6 expression through the activation of NF-κB in HSCs.
IL-32γ promotes integrin αvβ6 expression through the activation of NF-κB in HSCs.
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DOI：
10.3892/etm.2017.4956
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发表时间：
2017-10
影响因子：
2.7
通讯作者：
Hongcan Liu;Xingfei Pan;H. Cao;X. Shu;Hai-xia Sun;Jian-xi Lu;Jiayi Liang;Ka Zhang;Fengqin Zhu;Gang Li;Qi Zhang
中科院分区：
文献类型：
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作者：
Hongcan Liu;Xingfei Pan;H. Cao;X. Shu;Hai-xia Sun;Jian-xi Lu;Jiayi Liang;Ka Zhang;Fengqin Zhu;Gang Li;Qi Zhang
肝星状细胞（HSC）活化在肝纤维化的发病机制中起重要作用。然而，HSC活化的分子机制尚未完全了解。在本研究中，证实了白细胞介素-32 γ（IL-32γ）能够以剂量依赖性方式通过诱导整合素αv β6启动子活性来增强HSC中整合素α vβ6的表达。此外，确定了核因子κB（NF-κB）活化是IL-32γ诱导的整合素αvβ6表达所必需的。整合素αvβ6表达的增加能够激活HSC。这些结果表明，NF-κB活化是IL-32γ诱导整合素αvβ6表达并因此促进HSC活化所必需的。因此，IL-32γ激活HSC，因此可能与肝纤维化有关。这些结果可能有助于开发治疗肝纤维化的新的有效策略。
Hepatic stellate cell (HSC) activation is important in the pathogenesis of liver fibrosis. However, the molecular mechanism of HSC activation is not completely understood. In the present study, it was demonstrated that interleukin-32γ (IL-32γ) is capable of enhancing intefgrin αvβ6 expression by inducing integrin αvβ6 promoter activity in a dose-dependent manner in HSCs. Furthermore, it was determined that nuclear factor κB (NF-κB) activation is required for IL-32γ-induced integrin αvβ6 expression. Increased integrin αvβ6 expression is then able to activate HSCs. These results indicate that NF-κB activation is required for IL-32γ to induce integrin αvβ6 expression and consequently promote HSC activation. Therefore, IL-32γ activates HSCs and therefore may be associated with hepatic fibrogenesis. These results may enable the development of novel effective strategies to treat hepatic fibrosis.