PET Imaging of Angiogenesis.
PET Imaging of Angiogenesis.
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DOI：
10.1016/j.cpet.2009.04.011
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发表时间：
2009-01-01
期刊：
影响因子：
2.6
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Niu, Gang;Chen, Xiaoyuan
血管生成是一个高度受控的过程，依赖于促进因子和抑制因子的复杂平衡，涉及多种生理和病理过程。对调节血管生成的分子机制的全面理解导致了新的和更有效的治疗策略的设计。由于使用标准临床终点或通过寻找生理改善来检测治疗效果的灵敏度不足，已经开发了许多成像技术来评估组织血管的结构，功能和分子水平。成像有望为无创监测血管生成提供一种新的方法，以优化新的抗血管生成药物的剂量，并评估针对血管生成过程调节的治疗效果。所有这些方法都已成功地应用于临床前，并有望为动物实验中抗血管生成药物的开发提供帮助。本文将从功能水平和分子水平两方面对PET在血管生成成像中的应用进行综述。对于血管生成相关分子标记的PET成像，我们强调整合素αvβ3、VEGF/VEGFR和MMPs。
Angiogenesis is a highly-controlled process that is dependent on the intricate balance of both promoting and inhibiting factors, involved in various physiological and pathological processes. A comprehensive understanding of the molecular mechanisms that regulate angiogenesis has resulted in the design of new and more effective therapeutic strategies. Due to insufficient sensitivity to detect therapeutic effects by using standard clinical endpoints or by looking for physiological improvement, a multitude of imaging techniques have been developed to assess tissue vasculature on the structural, functional and molecular level. Imaging is expected to provide a novel approach to noninvasively monitor angiogenesis, to optimize the dose of new antiangiogenic agents and to assess the efficacy of therapies directed at modulation of the angiogenic process. All these methods have been successfully used preclinically and will hopefully aid in antiangiogenic drug development in animal studies. In this review article, the application of PET in angiogenesis imaging at both functional and molecular level will be discussed. For PET imaging of angiogenesis related molecular markers, we emphasize integrin αvβ3, VEGF/VEGFR, and MMPs.