The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells
The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells
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DOI：
10.1128/jvi.00323-12
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发表时间：
2012-09-01
影响因子：
5.4
通讯作者：
Ludwig, Stephan
中科院分区：
文献类型：
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作者：
Rueckle, Andrea;Haasbach, Emanuel;Ludwig, Stephan
甲型流感病毒（IAV）感染上皮细胞通过NF-kappa B信号通路激活NF-kappa B转录因子，调节抗病毒免疫反应和病毒复制。由于到目前为止对IAV感染后非典型NF-kappa B信号的功能几乎一无所知，我们测试了感染细胞的p52和RelB的激活。我们发现病毒NS1蛋白强烈抑制rig - i介导的非典型NF-kappa B激活和非典型靶基因CCL19的表达。
Influenza A virus (IAV) infection of epithelial cells activates NF-kappa B transcription factors via the canonical NF-kappa B signaling pathway, which modulates both the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-kappa B signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral NS1 protein strongly inhibits RIG-I-mediated noncanonical NF-kappa B activation and expression of the noncanonical target gene CCL19.