Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: The Bogalusa heart study
Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: The Bogalusa heart study
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DOI：
10.1016/s0026-0495(96)90060-8
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发表时间：
1996-02-01
影响因子：
9.8
通讯作者：
Berenson, GS
中科院分区：
文献类型：
--
作者：
Srinivasan, SR;Bao, WH;Berenson, GS
青春期超重被认为是长期发病率和死亡率的重要预测指标。青少年超重对成人超重和相关的多种心血管危险因素的影响在一个双民族(黑白)队列(N=783)中进行了研究，这些人在13到17岁的青少年和27到31岁的年轻成年人时参加了两次横断面调查。在两次调查中，根据年龄、种族和性别特定的身体质量指数(BMI)大于第75个百分位数或介于第25到50个百分位数，该队列被归类为青春期起病的成人超重(N=110)或瘦(N=81)。超重青少年在青年时期保持超重的风险从黑人男性的52%到黑人女性的62%不等。作为年轻人，超重组的体脂指标、收缩压和舒张压、脂蛋白胆固醇、胰岛素和血糖水平低于瘦组(P<；.01至P<；.0001)。与瘦队列相比，超重队列中临床公认的高血压和血脂异常的患病率分别增加了8.5倍和3.1倍至8.3倍(P<；0.05至P<；0.0001)。在超重队列中，父母糖尿病和高血压的患病率分别增加了2.4倍(P<；.01)和1.3倍(P<；.05)。总胆固醇/高密度脂蛋白胆固醇比率、胰岛素水平和收缩压的不利值(>；75%)仅在超重队列中出现聚集(P<；.0001)。因此，青春期超重持续到青春期，并对多种心血管危险因素有强烈的不利影响，需要在生命早期进行初级预防。(C)W.B.桑德斯公司1996年
Overweight in adolescence is considered an important predictor of long-term morbidity and mortality. The impact of adolescent overweight on adult overweight and related multiple cardiovascular risk factors was examined in a biracial (black-white) cohort (N = 783) who participated in two cross-sectional surveys as adolescents aged 13 to 17 years and as young adults aged 27 to 31 years. The cohort was categorized as adolescent-onset adult overweight (N = 110) or lean (N = 81) according to age-, race, and sex-specific body mass index (BMI) greater than the 75th percentile or between the 25th and 50th percentiles on both surveys. The risk for overweight adolescents to remain overweight as young adults ranged from 52% in black males to 62% in black females. As young adults, the overweight cohort showed adverse levels of body fatness measures, systolic and diastolic blood pressure, lipoprotein cholesterol, insulin, and glucose as compared with the lean cohort (P < .01 to P < .0001). The prevalence of clinically recognized hypertension and dyslipidemia increased 8.5-fold and 3.1- to 8.3 fold, respectively, in the overweight cohort versus the lean cohort (P < .05 to P < .0001). The prevalence of parental history of diabetes mellitus and hypertension increased 2.4-fold (P < .01) and 1.3-fold (P < .05), respectively, in the overweight cohort. Clustering of adverse values (> 75th percentile) for the total cholesterol to high-density lipoprotein (HDL) cholesterol ratio, insulin level, and systolic blood pressure occurred only among the overweight cohort (P < .0001). Thus, excess weight in adolescence persists into young adulthood, and has a strong adverse impact on multiple cardiovascular risk factors, requiring primary prevention early in life. (C) 1996 by W.B. Saunders Company