Experimental induction of hepatocellular carcinoma as a paradigm for carcinogenesis.
Experimental induction of hepatocellular carcinoma as a paradigm for carcinogenesis.
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肝细胞癌的实验诱导作为癌发生的范例。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
E. Farber
中科院分区：
文献类型：
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作者：
E. Farber
简要回顾了我们对由化学致癌剂引发的大鼠肝脏癌症逐步发展的了解现状。致癌过程由稀有肝细胞的一系列变化组成，其中一些变化通过克隆扩张形成结节而变得明显，结节由基因表达的长期渐进变化分隔开。细胞增殖对于癌症的起始、促进和进展以及癌症本身都很重要。简要回顾了一些已知的启动、促进和进展机制。强调了实验动物和人类癌症发展过程之间的明显相似性。简要讨论了该过程与癌基因和生长因子的可能关系。
The current status of our understanding of the step-by-step development of cancer in the liver in the rat, initiated with chemical carcinogens, is reviewed briefly. The carcinogenic process consists of a sequence of changes in rare hepatocytes, some of which become evident by clonal expansion to form nodules, separated by long periods of progressive change in gene expression. Cell proliferation is important in initiation, in promotion and in progression as well as in cancer per se. Some of the known mechanisms for initiation, promotion and progression are briefly reviewed. The apparent similarity between the process of cancer development in the experimental animal and in the human is emphasized. The possible relation of the process to oncogenes and growth factors is discussed briefly.