Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis.
Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis.
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DOI：
10.3109/1354750x.2015.1118539
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kapur NK
中科院分区：
文献类型：
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作者：
Morine KJ;Paruchuri V;Qiao X;Mohammad N;Mcgraw A;Yunis A;Jaffe I;Kapur NK
心力衰竭包括心肌纤维化和血管生成失调。我们探讨了纤维化和血管生成的生物标志物是否与HF严重程度相关。纤维化生物标志物[I型和III型前胶原（PIP, P3NP）， I型胶原的羧基端端肽（ICTP），基质金属蛋白酶（MMP2, MMP9）， MMP1组织抑制剂（TIMP1）]；在52例HF患者和19例对照组中检测血管新生[胎盘生长因子（PGF）、血管内皮生长因子（VEGF）、可溶性fms样酪氨酸激酶-1(sFlt1)]。HF患者P3NP、ICTP、MMP2、TIMP1、PGF和sFlt1水平升高，而PIP/ICTP、PGF/sFlt1和VEGF/sFlt1比值降低。在严重HF患者中，PIP/ICTP、MMP-9/TIMP1和VEGF/sFlt1比值最低。严重的心衰与胶原蛋白分解和血管生成减少有关。多标记方法可以指导心衰纤维化和血管生成的靶向治疗。
Heart failure involves myocardial fibrosis and dysregulated angiogenesis. We explored whether biomarkers of fibrosis and angiogenesis correlate with HF severity. Biomarkers of fibrosis [Procollagen Types I and III(PIP, P3NP), carboxyterminal-telopeptide of Type-I collagen(ICTP), matrix metalloproteases (MMP2, MMP9), tissue inhibitor of MMP1 (TIMP1)]; and angiogenesis [placental growth factor(PGF), vascular endothelial growth factor(VEGF), soluble Fms-Like Tyrosine Kinase-1(sFlt1)] were measured in 52 HF patients and 19 controls. P3NP, ICTP, MMP2, TIMP1, PGF and sFlt1 levels were elevated in HF, while PIP/ICTP, PGF/sFlt1, and VEGF/sFlt1 ratios were reduced. PIP/ICTP, MMP-9/TIMP1 and VEGF/sFlt1 ratios were lowest among patients with severe HF. Severe HF is associated with collagen breakdown and reduced angiogenesis. A multimarker approach may guide therapeutic targeting of fibrosis and angiogenesis in HF.