Baicalin Attenuates Joint Pain and Muscle Dysfunction by Inhibiting Muscular Oxidative Stress in an Experimental Osteoarthritis Rat Model
Baicalin Attenuates Joint Pain and Muscle Dysfunction by Inhibiting Muscular Oxidative Stress in an Experimental Osteoarthritis Rat Model
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DOI：
10.1007/s00005-018-0518-6
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发表时间：
2018-12-01
影响因子：
3.2
通讯作者：
Tang, Jian-jun
中科院分区：
文献类型：
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作者：
Chen, De-sheng;Cao, Jian-gang;Tang, Jian-jun
骨关节炎（OA）是最常见的退行性关节疾病，在成人中引起严重的疼痛和残疾。据报道，肌肉无力和炎症有助于骨关节炎的发展和进展。氧化应激在骨髓炎的肌肉功能障碍和炎症中起重要作用。黄芩苷是黄芩分离根的主要活性成分，具有抗氧化和抗炎作用。在本研究中，我们评估了黄芩苷对骨关节炎的潜在作用。我们建立实验性骨关节炎大鼠模型，将黄芩苷应用于大鼠，探讨黄芩苷对骨关节炎严重程度、肌肉功能障碍和氧化应激的潜在保护作用。黄芩苷可减轻大鼠OA的严重程度。黄芩苷通过增加柠檬酸合成酶活性、肌球蛋白重链IIa表达和降低白细胞介素6的产生来减轻OA大鼠的肌肉功能障碍。黄芩苷降低OA大鼠肌肉活性氧生成。黄芩苷抑制OA大鼠红细胞源性核因子2-样2的表达。黄芩苷通过抑制氧化应激减轻大鼠骨关节炎。
Osteoarthritis (OA) is the most common degenerative joint disease, and causes major pain and disability in adults. It has been reported that muscle weakness and inflammation contribute to osteoarthritis development and progression. Oxidative stress plays important roles in muscle dysfunction and inflammation in osteomyelitis. Baicalin, the major active constituent of the isolated root of Scutellarialateriflora Georgi, has been shown to have anti-oxidative and anti-inflammatory effects. In this study, we evaluated the potential effects of baicalin on osteoarthritis. We established experimental osteoarthritis rat model, applied baicalin to the rats, and then explored the potential protective effect of baicalin on osteoarthritis severity, muscle dysfunction, and oxidative stress. Baicalin alleviated severity of OA in rats. Baicalin application attenuated muscle dysfunction in OA rats by increasing citrate synthase activity, myosin heavy chain IIa expression, and decreasing interleukin 6 production. Baicalin decreased muscular reactive oxygen species generation in OA rats. Baicalin inhibited nuclear factor erythroid-derived 2-like 2 expression in OA rats. Baicalin attenuated osteoarthritis in rat by inhibiting oxidative stress.