The neurogenetics of alternative splicing.
The neurogenetics of alternative splicing.
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DOI：
10.1038/nrn.2016.27
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Zheng S
中科院分区：
文献类型：
--
作者：
Vuong CK;Black DL;Zheng S
选择性前体 mRNA 剪接是调节哺乳动物基因表达的关键机制，由专门的 RNA 结合蛋白控制。剪接的失调与多种神经系统疾病有关。我们描述了最近关于选择性剪接的小鼠遗传学研究，揭示了其在神经元发育和成熟神经元功能中的关键作用。我们讨论了理解发育过程和成人大脑中由调节剪接的蛋白质控制的广泛遗传程序所面临的挑战。
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.