The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma
The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma
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长链非编码RNA SNHG6-003作为竞争性内源RNA发挥作用，促进肝细胞癌的进展。
DOI：
10.1038/onc.2016.278
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发表时间：
2017-02-23
期刊：
影响因子：
8
通讯作者：
Liu, L.
中科院分区：
文献类型：
--
作者：
Cao, C.;Zhang, T.;Liu, L.
长链非编码RNA（lncRNA）在肝细胞癌（HCC）中表达失调。然而，lncRNA的功能和贡献在很大程度上仍然未知。在这里，我们确定了SNHG 6 -003在HCC中的关键作用。我们发现5个SNHG 6转录本在HCC组织中差异表达，而只有SNHG 6 -003具有致癌功能。SNHG 6 -003在肝癌细胞中的异位表达促进细胞增殖并诱导耐药，而SNHG 6 -003的敲低促进细胞凋亡。此外，SNHG 6 -003作为竞争性内源性RNA（ceRNA），有效地成为miR-26 a/B的海绵，从而调节转化生长因子-β-激活激酶1（TAK 1）的表达。重要的是，表达分析显示SNHG 6 -003和TAK 1在人类癌症中均上调，表现出共表达模式。在HCC患者中，SNHG 6 -003的高表达与肿瘤进展和较短的生存期密切相关。因此，靶向涉及SNHG 6 -003的ceRNA网络可以用作针对HCC的治疗策略。
The expression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellular carcinoma (HCC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of SNHG6-003 in HCC. We found that five SNHG6 transcripts were differentially expressed in HCC tissues while only the SNHG6-003 had an oncogenic function. Ectopic expression of SNHG6-003 in HCC cells promoted cell proliferation and induced drug resistance, whereas SNHG6-003 knockdown promoted apoptosis. Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1). Importantly, expression analysis revealed that both SNHG6-003 and TAK1 were upregulated in human cancers, exhibiting a co-expression pattern. In HCC patients, high expression of SNHG6-003 closely correlated with tumor progression and shorter survival. Thus, targeting the ceRNA network involving SNHG6-003 may be used as a treatment strategy against HCC.