Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas.
Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas.
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肠型和弥漫型胃腺癌中的幽门螺杆菌感染。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
Yuan Chang
中科院分区：
文献类型：
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作者：
J. Parsonnet;D. Vandersteen;J. Goates;R. Sibley;Jonathan Pritikin;Yuan Chang
胃癌可分为两种组织学类型：肠型和弥漫型。为了确定幽门螺杆菌（一种与胃炎相关的细菌）是否与任一种癌症类型相关，我们回顾了因胃癌而接受胃切除术的患者的胃组织切片。在37个有结肠癌证据的切片中，33个（89.2%）在非癌组织中含有幽门螺杆菌，而在22个有弥漫型癌症证据的切片中有7个（31.8%）含有幽门螺杆菌（比值比= 17.7; P <0.001）。当控制年龄、性别、研究中心和审查的章节数量时，这种关联仍然很强。幽门螺杆菌在消化道型胃癌中的患病率远远超过弥漫性疾病和美国正常人群中的患病率。这一发现表明，幽门螺杆菌可能是一个辅助因素，在发展的胃肠道型胃癌。
Gastric cancer can be divided into two histologic types: intestinal and diffuse. To determine whether Helicobacter pylori, a bacterium linked with gastritis, was associated with either cancer type, we reviewed histologic sections from stomachs of patients who had undergone gastrectomy for gastric cancer. Of 37 of the sections with evidence of intestinal-type cancer, 33 (89.2%) contained H pylori in noncancerous tissue compared with 7 (31.8%) of 22 of the sections with evidence of diffuse-type cancer (odds ratio = 17.7; P less than .001). This association remained strong when controlled for age, sex, site, and number of sections reviewed. The prevalence of H pylori in intestinal-type gastric cancer far exceeded the prevalence of H pylori in diffuse disease and that described in the normal US population. This finding suggests that H pylori may be a cofactor in development of intestinal-type gastric cancer.