Identification of Annexin A2 as a target protein for plant alkaloid matrine
Identification of Annexin A2 as a target protein for plant alkaloid matrine
复制标题
植物生物碱苦参碱靶蛋白膜联蛋白 A2 的鉴定
DOI：
10.1039/c7cc02227a
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发表时间：
2017
影响因子：
4.9
通讯作者：
Chai Yifeng
中科院分区：
文献类型：
--
作者：
Wang Dongyao;Cao Yan;Zheng Leyi;Lv Diya;Chen Langdong;Xing Xinrui;Zhu Zhenyu;Li Xiaoyu;Chai Yifeng
苦参碱是一种植物生物碱，是中药苦参的主要活性成分。苦参碱已显示出有效的抗癌活性，但其分子靶点和机制仍不清楚。使用光亲和标记方法，首次将膜联蛋白 A2 确定为癌细胞中苦参碱的直接结合靶点。
Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first time, Annexin A2 was identified as a direct-binding target of matrine in cancer cells.