The role of tumor-associated macrophage in tumor progression.
The role of tumor-associated macrophage in tumor progression.
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DOI：
10.2741/s299
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
K. Fukuda;A. Kobayashi;K. Watabe
中科院分区：
文献类型：
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作者：
K. Fukuda;A. Kobayashi;K. Watabe
肿瘤的进展不仅受癌细胞中转移促进和抑制基因的调节，而且还受到癌细胞和基质细胞之间相互作用的强烈影响。已知大量的炎症介质和白细胞促进癌症转移，并且肿瘤相关巨噬细胞（TAM）是炎症和癌症之间联系的关键参与者。TAM来源于通过炎性趋化因子募集到肿瘤中的外周血单核细胞。TAM被癌细胞激活后，具有促肿瘤生长的功能，包括表达多种生长因子、促进血管生成和抑制适应性免疫，其中许多因子在肿瘤转移中也起着重要作用。本文就TAM在实体瘤炎症微环境中的作用进行综述，并探讨其治疗的可能靶点。
The tumor progression is not only regulated by metastasis promoting and suppressing genes in cancer cells but it is also strongly influenced by the interaction between cancer cells and the stromal cells. An abundance of inflammatory mediators and leukocytes has been known to promote cancer metastasis, and tumor associated macrophages (TAM) are the key players in the link between inflammation and cancer. TAM are derived from peripheral blood monocytes that are recruited into the tumor by inflammatory chemokines. Upon activation by cancer cells, TAM gain the ability of pro-tumoral functions including expression of various growth factors, promotion of angiogenesis and suppression of adaptive immunity, and many of these factors also play critical roles in cancer metastasis. In this review, we will summarize the recent information about the function of TAM in the inflammatory micro-environment of solid tumors and discuss the potential targets for future therapeutic approaches.