One-step procedure for enhancing the antibacterial and antioxidant properties of a polysaccharide polymer: Kojic acid grafted onto chitosan.
One-step procedure for enhancing the antibacterial and antioxidant properties of a polysaccharide polymer: Kojic acid grafted onto chitosan.
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DOI：
10.1016/j.ijbiomac.2018.03.007
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发表时间：
2018-07
影响因子：
8.2
通讯作者：
Xiaoli Liu;Q. Jiang;W. Xia
中科院分区：
文献类型：
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作者：
Xiaoli Liu;Q. Jiang;W. Xia
本工作的目的是开发一种基于天然吡喃酮化合物(曲酸)和壳寡糖(COS)的无毒生物活性材料。采用环境友好法一步法制备了壳寡糖-N-曲酸聚合物(COS-N-KA)。然后，对制备的水溶性COS衍生物COS-N-KA的物化性质和生物活性进行了评价。用UV-Vis、FTIR、~1H和~(13)C核磁共振谱、MW、PID、TGA、水溶性、溶血实验和动物毒性实验对聚合物进行了表征。抗氧化性和抗菌活性测定表明，COS-N-KA显著提高了抗菌活性和抗氧化性，显著高于游离COS和KA。因此，SLAC KM株对人红细胞的低溶血活性和对雌性小鼠的无毒作用使这种新型聚合物材料成为一种在食品和制药工业中有前景的有效化合物。
The purpose of this work was to develop a nontoxic bioactive material based on a natural pyrone compound (kojic acid, KA) and chitosan oligosaccharides (COS). The bioactive material, chitosan oligosaccharide-N-kojic acid polymer (COS-N-KA), was prepared by one-step environmentally friendly approach. Then, the physicochemical properties and biological activities of COS-N-KA as a prepared water-soluble COS derivative were evaluated. The polymer was characterized by using UV–vis, FTIR,1H NMR, and13C NMR spectroscopy, Mw, PID, TGA, water solubility, hemolysis assay, and animal toxicity studies. Particularly, the antioxidant and antimicrobial assays revealed that COS-N-KA significantly enhanced the antimicrobial and antioxidant activities, which remarkably stronger than that of free COS and KA. Hence, the low hemolytic activity to human red blood cells, and nontoxic to female mice of SLAC KM strain made this novel polymer material a promising and effective compound for food and pharmaceutical industries.