Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines.
Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines.
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新兴的基于生物材料的个性化原位癌疫苗治疗策略。
DOI：
10.1016/j.biomaterials.2021.121297
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发表时间：
2022-01
期刊：
影响因子：
14
通讯作者：
Grattoni A
中科院分区：
文献类型：
--
作者：
Viswanath DI;Liu HC;Huston DP;Chua CYX;Grattoni A
肿瘤免疫学的里程碑式成功导致了增强宿主免疫系统的治疗方法的发展，以根除局部和远处的肿瘤，并在一部分患者中有效减少肿瘤。然而，当前的免疫治疗方式在涉及免疫冷肿瘤和实体瘤时通常表现出有限的成功。在这里，我们描述了各种生物材料在配制癌症疫苗作为癌症免疫疗法的一种形式中的作用，寻求利用宿主免疫系统来激活和扩增肿瘤特异性 T 细胞。基于生物材料的癌症疫苗通过利用针对肿瘤特异性抗原的细胞募集和激活来增强癌症免疫循环。在这篇综述中，我们讨论了基于生物材料的疫苗策略，以诱导介导抗肿瘤免疫所需的淋巴细胞反应。我们专注于通过免疫刺激梯度选择性吸引树突状细胞，激活它们对抗呈递的肿瘤特异性抗原，并诱导与次级淋巴器官中的 T 细胞有效交叉呈递，从而产生免疫力的策略。我们认为个性化癌症疫苗是有希望的目标，可以产生针对患者和肿瘤特异性抗原的长期全身免疫力，以确保长期癌症缓解。
Landmark successes in oncoimmunology have led to development of therapeutics boosting the host immune system to eradicate local and distant tumors with impactful tumor reduction in a subset of patients. However, current immunotherapy modalities often demonstrate limited success when involving immunologically cold tumors and solid tumors. Here, we describe the role of various biomaterials to formulate cancer vaccines as a form of cancer immunotherapy, seeking to utilize the host immune system to activate and expand tumor-specific T cells. Biomaterial-based cancer vaccines enhance the cancer-immunity cycle by harnessing cellular recruitment and activation against tumor-specific antigens. In this review, we discuss biomaterial-based vaccine strategies to induce lymphocytic responses necessary to mediate anti-tumor immunity. We focus on strategies that selectively attract dendritic cells via immunostimulatory gradients, activate them against presented tumor-specific antigens, and induce effective cross-presentation to T cells in secondary lymphoid organs, thereby generating immunity. We posit that personalized cancer vaccines are promising targets to generate long-term systemic immunity against patient- and tumor-specific antigens to ensure long-term cancer remission.
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影响因子：
3.7
作者：
Ali, Omar A.;Doherty, Ed;Emerich, Dwaine F.
通讯作者：
Emerich, Dwaine F.
影响因子：
0.9
作者：
Batra, Jitender;Bekal, Rajesh Kumar;Vakade, Chinmay Dilip
通讯作者：
Vakade, Chinmay Dilip
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
可注射冷冻凝胶的全细胞癌疫苗。
影响因子：
16.6
作者：
Bencherif SA;Warren Sands R;Ali OA;Li WA;Lewin SA;Braschler TM;Shih TY;Verbeke CS;Bhatta D;Dranoff G;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
50.3
作者：
Anderson KG;Stromnes IM;Greenberg PD
通讯作者：
Greenberg PD