Immunological effects of silica and asbestos.
Immunological effects of silica and asbestos.
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发表时间：
2007-08
影响因子：
24.1
通讯作者：
T. Otsuki;M. Maeda;S. Murakami;H. Hayashi;Y. Miura;M. Kusaka;T. Nakano;K. Fukuoka;T. Kishimoto;F. Hyodoh;A. Ueki;Y. Nishimura
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文献类型：
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作者：
T. Otsuki;M. Maeda;S. Murakami;H. Hayashi;Y. Miura;M. Kusaka;T. Nakano;K. Fukuoka;T. Kishimoto;F. Hyodoh;A. Ueki;Y. Nishimura
矽肺患者（锡尔斯）和接触石棉的患者不仅会发生呼吸系统疾病，而且还会发生某些免疫系统疾病。特别是，SIL有时会使自身免疫性疾病复杂化，如系统性硬皮病、类风湿性关节炎（称为卡普兰综合征）和系统性狼疮性肾炎。此外，接触石棉的患者常发生肺癌、恶性间皮瘤等恶性并发症，可能与肿瘤免疫力降低有关。虽然二氧化硅引起的自身免疫性疾病已被解释为二氧化硅的副作用，但需要更精确的分析，并应反映免疫分子研究结果的最新进展。简要总结了我们的调查有关的二氧化硅/石棉的免疫学效应。免疫分子研究的最新进展导致石棉和二氧化硅的免疫学效应的详细分析。两者都影响免疫活性细胞，这些影响可能与矽肺和石棉暴露患者并发症的病理生理学发展有关，例如分别发生自身免疫性疾病和恶性肿瘤。此外，免疫学分析可能导致新的临床工具的发展，用于疾病的病理生理学方面的修改，例如使用细胞介导的疗法、各种细胞因子和分子靶向疗法来调节自身免疫或肿瘤免疫。特别是，由于与石棉有关的恶性肿瘤的发病率正在增加，而且这种恶性肿瘤自2005年夏天以来在日本已成为一个医疗和社会问题，因此应集中努力开发治疗这些疾病的方法，以消除全国的焦虑。
Silicosis patients (SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular, SIL sometimes complicates autoimmune diseases such as systemic scleroderma, rheumatoid arthritis (known as Caplan syndrome), and systemic lupus erythematoses. In addition, malignant complications such as lung cancer and malignant mesothelioma often occur in patients exposed to asbestos, and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica, more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively. In addition, immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies, various cytokines, and molecule-targeting therapies. In particular, as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety.