Intravascular ultrasound elastography: assessment and imaging of elastic properties of diseased arteries and vulnerable plaque.
Intravascular ultrasound elastography: assessment and imaging of elastic properties of diseased arteries and vulnerable plaque.
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DOI：
10.1016/s0929-8266(98)00043-3
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发表时间：
1998-08-01
期刊：
影响因子：
--
通讯作者：
Bom, N
中科院分区：
文献类型：
--
作者：
de Korte, C L;Cespedes, E I;Bom, N
目的：血管内弹性成像涉及使用血管内超声(IVUS)测量局部弹性特性的方法。通过应变可以测量血管壁和动脉粥样硬化的弹性性质。这些力学性质的知识有助于指导介入手术(球囊扩张、消融)和斑块脆弱性的检测。方法：利用30 MHz回声导管在两个血管内压水平下采集的IVUS图像之间的相对局部位移，构建弹性图和掌纹图(应变图像)。结果：在模拟动脉粥样硬化血管的凝胶模型上的实验证明，弹性成像能够独立于回声对比度识别软斑块和硬斑块。人体动脉的体外实验表明，血管内弹性成像技术可以根据斑块的力学特性识别不同的斑块类型。仅使用IVUS图像无法识别这些斑块。还可以检测到机械应力升高的区域。这些应力集中与斑块破裂有关。结论：血管内弹性成像提供了血管内超声图像中经常无法获得或不确定的信息，因此可能有助于动脉粥样硬化性疾病的诊断和治疗。
OBJECTIVE: Intravascular elastography is concerned with methods for measuring the local elastic properties using intravascular ultrasound (IVUS). The elastic properties of the vessel wall and atheroma can be measured through the strain. Knowledge of these mechanical properties is useful for guiding interventional procedures (balloon dilatation, ablation) and detection of plaque vulnerability.METHODS: Elastograms and palpograms (images of strain) were constructed using the relative local displacements between IVUS images acquired at two levels of intravascular pressure with a 30-MHz echo catheter. These displacements were estimated from the time shift between gated radio-frequency echo signals using cross-correlation algorithms with interpolation around the peak.RESULTS: Experiments on gel-based phantoms mimicking atherosclerotic vessels demonstrated the capability of elastography to identify soft and hard plaques independently of the echogenicity contrast. In vitro experiments on human arteries have demonstrated the potential of intravascular elastography to identify different plaque types based on the mechanical properties. These plaques could not be identified using the IVUS image alone. Regions with elevated mechanical stress could also be detected. These stress concentrations are related to plaque fracture.CONCLUSION: Intravascular elastography provides information that is frequently unavailable or inconclusive from the IVUS image and therefore may assist in the diagnosis and treatment of atherosclerotic disease.