On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X7 receptor antagonist A-438079
On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X7 receptor antagonist A-438079
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DOI：
10.1007/s00702-010-0400-0
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Rivera, Alicia
中科院分区：
文献类型：
--
作者：
Marcellino, Daniel;Suarez-Boomgaard, Diana;Rivera, Alicia
使用P2 X（7）竞争性拮抗剂A-438079在帕金森病单侧6-OHDA大鼠模型中评价了ATP门控受体P2 X（7）的作用。黑质P2 X（7）免疫反应主要位于小胶质细胞，但也存在于星形胶质细胞。A-438079部分但显著地阻止了6-OHDA诱导的纹状体DA储存的消耗。然而，这与DA细胞损失的减少无关。阻断P2 X（7）受体可能代表了帕金森病纹状体DA终末的一种新的保护策略，值得进一步研究。
The role of the ATP-gated receptor, P2X(7), has been evaluated in the unilateral 6-OHDA rat model of Parkinson's disease using the P2X(7) competitive antagonist A-438079. Nigral P2X(7) immunoreactivity was mainly located in microglia but also in astroglia. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. However, this was not associated with a reduction of DA cell loss. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease and warrants further future investigation.