Microbial Infections Are a Risk Factor for Neurodegenerative Diseases.
Microbial Infections Are a Risk Factor for Neurodegenerative Diseases.
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DOI：
10.3389/fncel.2021.691136
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发表时间：
2021
影响因子：
5.3
通讯作者：
Funk KE
中科院分区：
文献类型：
--
作者：
Lotz SK;Blackhurst BM;Reagin KL;Funk KE
神经退行性疾病，如阿尔茨海默病、帕金森病和肌萎缩性侧索硬化，包括以神经系统功能的进行性丧失为特征的疾病家族。神经炎症越来越多地被认为与许多神经退行性疾病有关，但它是否是疾病过程的原因或后果尚不清楚。越来越感兴趣的是微生物感染在激发退行性神经炎症反应中的作用以及可能调节这些反应的遗传因子。微生物感染通过激活脑驻留免疫细胞和浸润外周免疫细胞引起中枢神经系统内的炎症。这些反应是保护大脑免受致命感染所必需的，但也可能诱发导致神经退行性变的神经病理学变化。这篇综述讨论了微生物感染可能增加神经退行性疾病易感性的分子和细胞机制。阐明这些机制对于开发预防神经退行性疾病发作和减缓其进展的靶向治疗方法至关重要。
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive loss of nervous system function. Neuroinflammation is increasingly recognized to be associated with many neurodegenerative diseases but whether it is a cause or consequence of the disease process is unclear. Of growing interest is the role of microbial infections in inciting degenerative neuroinflammatory responses and genetic factors that may regulate those responses. Microbial infections cause inflammation within the central nervous system through activation of brain-resident immune cells and infiltration of peripheral immune cells. These responses are necessary to protect the brain from lethal infections but may also induce neuropathological changes that lead to neurodegeneration. This review discusses the molecular and cellular mechanisms through which microbial infections may increase susceptibility to neurodegenerative diseases. Elucidating these mechanisms is critical for developing targeted therapeutic approaches that prevent the onset and slow the progression of neurodegenerative diseases.
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
9.9
作者：
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DOI：
10.1016/j.mcn.2016.12.006
发表时间：
2017-03
期刊：
Molecular and cellular neurosciences
影响因子：
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通讯作者：
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影响因子：
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作者：
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