Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.
Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.
复制标题
主动与被动吸收动力学作为 S-2-(3-氨基丙氨基)-乙基硫代磷酸选择性保护正常组织的基础。
作者：
J. Yuhas
通过对S-2-(3-氨基丙氨基)乙基硫代磷酸(WR-2721)在小鼠、大鼠和兔的正常组织和实体瘤中的吸收动力学的体内和体外分析，已证明正常组织逆着浓度梯度主动浓缩WR-2721，而实体瘤被动吸收它，或者，如果肿瘤中存在活性浓度的WR-2721，则其作用速率相对于正常组织要低得多。这些观察结果可以解释 WR-2721 选择性保护正常组织免受辐射和烷化剂损伤的能力。
Through an in vivo and in vitro analysis of the absorption kinetics of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) in the normal tissues and solid tumors of mice, rats, and rabbits, it has been demonstrated that normal tissues actively concentrate WR-2721 against a concentration gradient, whereas solid tumors passively absorb it, or, if active concentration of WR-2721 is present in tumors, it operates at a far reduced rate relative to normal tissues. These observations can account for the ability of WR-2721 to selectively protect normal tissues against both radiation and alkylating agent injury.