Effects of inorganic ions and of plasma proteins on the aggregation of blood platelets by adenosine diphosphate
Effects of inorganic ions and of plasma proteins on the aggregation of blood platelets by adenosine diphosphate
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无机离子和血浆蛋白对二磷酸腺苷血小板聚集的影响
DOI：
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
M. Cross
中科院分区：
文献类型：
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作者：
G. Born;M. Cross
在许多已被测试的核苷酸中，二磷酸腺苷(ADP)单独能引起血浆中的血小板聚集(Gaarder，Jonsen，Laland，Hellem&Owren，1961)。凝血酶和儿茶酚胺等其他物质也会引起血小板聚集，但ADP特别令人感兴趣，因为血小板中含有相对较高浓度的其前体三磷酸腺苷(Born，1958)，而且有证据表明，凝血酶和儿茶酚胺也通过涉及ADP的反应诱导聚集(Kaser-Glanzmann&Liischer，1962；Clayton&Cross，1963)。我们已经用浊度法研究了血浆中的聚集(Born，1962，a，b；Born&Cross，1963a)。为了更多地了解这一现象，我们现在使用了从血浆中分离出来的猪血小板，并将其重新悬浮在更简单的介质中。其中一些工作已被简要报告(Born&Cross，1963b)，另一些结果已在其他地方得到证实(Haslam，个人交流)。
Adenosine diphosphate (ADP), alone amongst a number of nucleotides which have been tested, brings about the aggregation of blood platelets in plasma (Gaarder, Jonsen, Laland, Hellem & Owren, 1961). Other substances such as thrombin and the catecholamines also cause platelets to aggregate, but ADP is of special interest because platelets contain a relatively high concentration of its precursor, adenosine triphosphate (Born, 1958), and because there is evidence to suggest that thrombin and the catecholamines also induce aggregation through a reaction involving ADP (Kaser-Glanzmann & Liischer, 1962; Clayton & Cross, 1963). We have already investigated aggregation in plasma by a turbidimetric method (Born, 1962, a, b; Born & Cross, 1963a). To learn more about the phenomenon we have now used pigs' platelets separated from plasma and resuspended in simpler media. Some of this work has been reported briefly (Born & Cross, 1963b) and some of the results have been confirmed elsewhere (Haslam, personal communication).