Studies on the aetiology of byssinosis
Studies on the aetiology of byssinosis
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棉尘病的病因学研究
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
F. Lucas
中科院分区：
文献类型：
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作者：
G. Taylor;A. Massoud;F. Lucas
泰勒，G.，Massoud，A. A. E、和Lucas，F.（1971）.Brit. J. industry. Med.，28，143-151。棉纤维沉着症的病因学研究。从棉花中提取了一种基于无色花青素的浓缩多酚。已使用沉淀素和被动凝集技术证明了该材料与人血清之间的反应。用被动凝集法检测了196名无棉屑病工人、177名棉屑病工人和203名对照的血清与浓缩多酚的反应性。在cardroom工人和对照组之间，以及在byssinotic和非byssinotic cardroom工人之间，平均滴度存在显著差异。结果表明，虽然平均滴度在非棉纤维病cardroom工人保持相对恒定的就业时间，这些cardroom工人患有棉纤维病的滴度显示出一个渐进的上升与cardroom暴露的时间。正常对照组和非棉酚性心脏病室工作人员吸入浓缩多酚溶液既不产生症状，也不改变FEV 1·0或FVC。另一方面，棉纤维病车间工人吸入该物质引起的症状与周一在车间接触时出现的症状相同。由于棉纤维沉着症的主观性质，该吸入研究作为双盲试验重复进行，完全证实了上述观察结果。
Taylor, G., Massoud, A. A. E., and Lucas, F. (1971).Brit. J. industr. Med.,28, 143-151. Studies on the aetiology of byssinosis. A condensed polyphenol based on leucocyanidin has been extracted from the cotton plant. The reaction between this material and human serum has been demonstrated using both a precipitin and a passive agglutination technique. Sera from 196 cardroom workers not suffering from byssinosis, 177 byssinotic cardroom workers, and 203 controls were tested for reactivity with the condensed polyphenol using the passive agglutination technique. Significant differences in mean titres were obtained between cardroom workers and controls and between byssinotic and non-byssinotic cardroom workers. It was shown that while the mean titre in non-byssinotic cardroom workers remains relatively constant with respect to duration of employment, the titre in those cardroom workers suffering from byssinosis shows a progressive rise with duration of cardroom exposure. Inhalation of solutions of the condensed polyphenol by normal control subjects and by non-byssinotic cardroom workers produced neither symptoms nor changes in FEV1·0 or FVC. On the other hand, inhalation of the material by byssinotic cardroom workers induced symptoms identical with those experienced on exposure in the cardroom on Mondays. Because of the subjective nature of byssinosis, this inhalational study was repeated as a double-blind trial which completely confirmed the above observations.