Personality influences limbic-cortical interactions during sad mood induction
Personality influences limbic-cortical interactions during sad mood induction
复制标题
DOI：
10.1016/j.neuroimage.2003.08.022
复制
发表时间：
2003-12-01
期刊：
影响因子：
5.7
通讯作者：
Mayberg, HS
中科院分区：
文献类型：
--
作者：
Keightley, ML;Seminowicz, DA;Mayberg, HS
目前的研究检查了短暂情绪压力下边缘皮质的激活与人格风格的关系。在悲伤情绪挑战期间，使用正电子发射断层扫描 (PET) 测量局部脑血流量 (rCBF) 来识别以腹侧扣带皮层 (Cg25) 为中心的边缘皮质网络，该网络显示出针对特定消极和积极情绪特征模式选择的个体存在差异，并由 NEO 人格量表修订版索引。健康受试者在神经质的抑郁方面得分较低（N3），在外向性的积极情绪方面得分较高（E6），与那些在抑郁方面得分较高（N3）但在积极情绪方面得分较低（E6）的受试者进行比较，这些特征的组合先前与情绪反应的正常变化有关。扫描分析旨在进一步表征先前在健康受试者和抑郁患者的负面情绪研究中报道的 Cg25 活性的已知变化。偏最小二乘 (PLS) 是一种多变量技术，展示了一个不同的 Cg25 介导的网络，该网络可以区分气质消极 (NAS) 和气质积极 (PAS) 受试者，从而在这些特征情感风格的特定组合与抑郁症易感性之间提供潜在的神经联系。 (C) 2003 Elsevier Inc. 保留所有权利。
The current study examined limbic-cortical activation under transient emotional stress as a function of personality style. A ventral cingulate (Cg25)-centred limbic-cortical network was identified using positron emission tomography (PET) measures of regional cerebral blood flow (rCBF) during a sad mood challenge that demonstrated differences for individuals selected for specific patterns of Negative and Positive emotional traits, indexed by the NEO Personality Inventory-Revised. Healthy subjects scoring both low on the dispositional Depression facet of Neuroticism (N3) and high on the Positive Emotions facet of Extraversion (E6) were compared to those scoring high on the Depression facet (N3) and low on Positive Emotions (E6), a combination of traits previously linked to normal variations in mood reactivity. Scan analyses were designed to further characterize known variations in Cg25 activity previously reported in studies of negative mood in both healthy subjects and depressed patients. A multivariate technique, partial least squares (PLS) demonstrated a divergent Cg25-mediated network that differentiated temperamentally negative (NAS) from temperamentally positive (PAS) subjects providing a potential neural link between these specific combinations of trait affective styles and vulnerability to depression. (C) 2003 Elsevier Inc. All rights reserved.