Relevant human tissue resources and laboratory models for use in endometriosis research.
Relevant human tissue resources and laboratory models for use in endometriosis research.
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DOI：
10.1111/aogs.13119
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发表时间：
2017-06
影响因子：
4.3
通讯作者：
Saunders PTK
中科院分区：
文献类型：
--
作者：
Greaves E;Critchley HOD;Horne AW;Saunders PTK
子宫内膜异位症的特征是子宫内膜样组织在子宫外生长，最常见于盆腔腹膜和卵巢。尽管它对某些女性来说可能没有症状，但对另一些女性来说，它可能会导致衰弱性疼痛、不孕或包括疲劳在内的其他症状。目前的研究是针对了解复杂的病因和病理生理学的障碍，并在新的非手术治疗方法，缺乏目前的医疗管理不必要的副作用的发展。用于子宫内膜异位症研究的工具分为两大类;患者来源的组织和液体（以及从这些来源分离的细胞）或基于使用细胞或动物的模型。在这篇综述中，我们讨论了在子宫内膜异位症研究中使用这些工具报告数据的文献，并强调了每个工具的优点和缺点。尽管文献中报道了许多不同的模型，但只有通过仔细的实验设计和从患有和不患有子宫内膜异位症的患者中选择最合适的人体组织以及生理学相关的体外和体内实验室模型的组合，才能促进假设驱动的研究。
Endometriosis is characterized by the growth of endometrium‐like tissue outside the uterus, most commonly on the pelvic peritoneum and ovaries. Although it may be asymptomatic in some women, in others it can cause debilitating pain, infertility or other symptoms including fatigue. Current research is directed both at understanding the complex etiology and pathophysiology of the disorder and at the development of new nonsurgical approaches to therapy that lack the unwanted side effects of current medical management. Tools for endometriosis research fall into two broad categories; patient‐derived tissues, and fluids (and cells isolated from these sources) or models based on the use of cells or animals. In this review, we discuss the literature that has reported data from the use of these tools in endometriosis research and we highlight the strengths and weaknesses of each. Although many different models are reported in the literature, hypothesis‐driven research will only be facilitated with careful experimental design and selection of the most appropriate human tissue from patients with and without endometriosis and combinations of physiologically relevant in vitro and in vivo laboratory models.