Effect of Auditory Evoked Potential-Guided Anaesthesia on Consumption of Anaesthetics and Early Postoperative Cognitive Dysfunction: a randomised controlled trial
Effect of Auditory Evoked Potential-Guided Anaesthesia on Consumption of Anaesthetics and Early Postoperative Cognitive Dysfunction: a randomised controlled trial
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DOI：
10.1097/eja.0b013e328340dbb9
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发表时间：
2011-03-01
影响因子：
3.6
通讯作者：
Berggren, Lars
中科院分区：
文献类型：
--
作者：
Jildenstal, Pether K.;Hallen, Jan L.;Berggren, Lars
非心脏手术后的术后认知功能障碍（POCD）是某些类型患者的常见问题。本研究旨在评估听觉诱发电位（AEP）引导下麻醉对麻醉药物需求的影响及其对POCD.Methods的影响，年龄在18至92岁之间的眼科手术患者450例全身麻醉随机分为两组。A组（AEP组），麻醉深度（DoA）目标是AEP指数（AAI）在15至25之间。C组（对照组）根据临床体征指导DoA。使用标准化算法，通过补液和血管加压药治疗低血压。结果A组麻醉药物用量显著低于C组：异丙酚92.5 ± 26.5mg对103.8 ± 39.5mg（P = 0.0001），C组麻醉药物用量显著低于A组（P = 0.0001），A组麻醉药物用量显著低于C组（P = 0.0001），C组麻醉药物用量显著低于A组（P = 0.0001）。
Background Post-operative cognitive dysfunction (POCD) after non-cardiac surgery is a well known problem in some categories of patients. This study aims to evaluate the influence of auditory evoked potential (AEP)-guided anaesthesia on the requirement for anaesthetic drugs and their influence on POCD.Methods Four hundred and fifty patients aged between 18 and 92 years scheduled for ophthalmic surgery under general anaesthesia were assigned randomly to one of two groups. In group A (AEP group), the depth of anaesthesia (DoA) was aimed at an AEP index (AAI) between 15 and 25. In group C (control group), DoA was guided by clinical signs. Hypotension was treated with fluids and vasopressors using a standardised algorithm. A mini-mental test and the Cognitive Failure Questionnaire were used to evaluate cognitive function.Results Anaesthetic drug requirements were significantly lower in group A than in group C: propofol 92.5 +/- 26.5 vs. 103.8 +/- 39.5 mg (P =