Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum.
Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum.
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异种C型RNA病毒感染的大鼠细胞的化学转化及其病毒特异性抗血清的抑制。
DOI：
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发表时间：
1977
影响因子：
11.1
通讯作者：
R. Huebner
中科院分区：
文献类型：
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作者：
P. Price;W. Suk;R. Peters;R. Gilden;R. Huebner
用从NIH Swiss小鼠或C57 L近交系小鼠中分离的异嗜性小鼠C型RNA病毒感染的Fischer大鼠胚胎细胞，在单独处理均不足以诱导转化的条件下，用4-硝基喹啉氧化物或3-甲基胆蒽转化。转化依赖于在化学处理时存在活跃生长的病毒。异嗜性病毒特异性抗体中和病毒，并抑制3-甲基胆蒽的恶性转化。
Fischer rat embryo cells infected with xenotropic mouse type-C RNA viruses isolated from either NIH Swiss mice or C57L inbred mice were transformed by 4-nitroquinoline oxide or 3-methylcholanthrene under conditions in which neither treatment alone sufficed to induce transformation. Transformation was dependent on the presence of actively growing virus at the time of chemical treatment. Specific antibody to xenotropic virus neutralized the virus and inhibited malignant transformation by 3-methylcholanthrene.