Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.
Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.
复制标题
DOI：
10.1089/jir.2013.0108
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
I. Vlasova-St Louis;P. Bohjanen
中科院分区：
文献类型：
--
作者：
I. Vlasova-St Louis;P. Bohjanen
细胞因子是细胞通讯所必需的，可以对外部刺激做出反应，这对于生存和维持体内平衡至关重要。细胞因子网络的功能障碍对细胞内和细胞外环境产生有害影响。因此，细胞因子的表达以及细胞因子向靶细胞传递的信号在多个水平（包括转录和转录后水平）上受到严格调节至关重要。在这里，我们简要总结了富含 AU 的元件 (ARE) 在转录后水平调节细胞因子基因表达的作用，并描述了富含 GU 的元件 (GRE) 在协调细胞因子信号传导调节中的作用。 GRE 作为控制细胞激活、生长和凋亡的蛋白质转录后调节因子。 GRE 和 ARE 协同工作以协调细胞因子信号转导途径。细胞因子信号传导的精确调控尤为重要，因为其失调可能导致人类疾病。
Cytokines are necessary for cell communication to enable responses to external stimuli that are imperative for the survival and maintenance of homeostasis. Dysfunction of the cytokine network has detrimental effects on intra- and extracellular environments. Thus, it is critical that the expression of cytokines and the signals transmitted by cytokines to target cells are tightly regulated at numerous levels, including transcriptional and post-transcriptional levels. Here, we briefly summarize the role of AU-rich elements (AREs) in the regulation of cytokine gene expression at the post-transcriptional level and describe a role for GU-rich elements (GREs) in coordinating the regulation of cytokine signaling. GREs function as post-transcriptional regulators of proteins that control cellular activation, growth, and apoptosis. GREs and AREs work in concert to coordinate cytokine signal transduction pathways. The precise regulation of cytokine signaling is particularly important, because its dysregulation can lead to human diseases.